Scientists Engineered a Plant To Produce 5 Different Psychedelics At Once
Plants, toads, and mushrooms "can all produce psychedelic substances," writes ScienceAlert.
"And now their powers have been combined in one plant."
[S]cientists have taken the genes these organisms use to make five natural psychedelics and introduced them into a tobacco plant ( Nicotiana benthamiana), which then produced all five compounds simultaneously. As interest grows in psychedelics as potential treatments for illnesses such as depression, anxiety, and PTSD, the newly developed system could offer scientists a new way to produce these compounds for research purposes...
[P]rogress in this field remains limited, in part due to regulatory restrictions, underscoring the need for more research. This creates practical challenges for scientists. "Traditionally, the supply of psychedelics relies on natural producers, mainly plants, fungi, and the Sonoran Desert toad," the researchers write. "Harvesting these organisms for their psychoactive compounds raises ecological and ethical concerns, being increasingly threatened by habitat loss and overexploitation..."
[T]he team carefully monitored the plant's production of five psychedelic tryptamines: DMT originally from plants; psilocin and psilocybin from mushrooms; and bufotenin and 5-MeO-DMT from toads. The modified tobacco plants were found to produce all five compounds simultaneously.
The article points out that the researchers "also took it a step further." By tweaking the enzymes they were able to "produce modified versions of the compounds that do not naturally occur in plants, and which may also have therapeutic value."
"And now their powers have been combined in one plant."
[S]cientists have taken the genes these organisms use to make five natural psychedelics and introduced them into a tobacco plant ( Nicotiana benthamiana), which then produced all five compounds simultaneously. As interest grows in psychedelics as potential treatments for illnesses such as depression, anxiety, and PTSD, the newly developed system could offer scientists a new way to produce these compounds for research purposes...
[P]rogress in this field remains limited, in part due to regulatory restrictions, underscoring the need for more research. This creates practical challenges for scientists. "Traditionally, the supply of psychedelics relies on natural producers, mainly plants, fungi, and the Sonoran Desert toad," the researchers write. "Harvesting these organisms for their psychoactive compounds raises ecological and ethical concerns, being increasingly threatened by habitat loss and overexploitation..."
[T]he team carefully monitored the plant's production of five psychedelic tryptamines: DMT originally from plants; psilocin and psilocybin from mushrooms; and bufotenin and 5-MeO-DMT from toads. The modified tobacco plants were found to produce all five compounds simultaneously.
The article points out that the researchers "also took it a step further." By tweaking the enzymes they were able to "produce modified versions of the compounds that do not naturally occur in plants, and which may also have therapeutic value."
Read more of this story at Slashdot.
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