Mobile Version
Free Internet Press
  Uncensored News For Real People


FIP Year In Review

FIP Month in Review

FIP Archive Search




2014-07-09
R.I.P. William 'Bill' Herbert Kelder - Intellpuke

2013-11-28
Gamers Donate 37,500 Pounds Of Food To Needy

2013-09-30
Statement From The Whitehouse Regarding The Government Shutdown

2013-09-29
An Open Response To 'Organizing for Action'

2013-08-26
Bayou Corne: The Biggest Ongoing Disaster In The U.S. You Have Not Heard Of

2013-04-21
Boston Mayor Hopes Feds 'Throw the Book' at Marathon Bombing Suspect

2013-04-19
Boston Police Closing In On Suspects

2013-04-15
2 Explosions At Boston Marathon. 2 Dead, Many Injured.

2013-01-03
The Press vs Citizens Rights and Privacy - Act 3

2012-12-30
CBS News - Year In Review 2012

Nature.com - 366 Days: 2012 In Review

The Guardian - 2012 In Review: An Interactive Guide To The Year That Was

TruTV - The Biggest Conspiracy Theories of 2012

Colbert Nation: 2012: A Look Back

FIP Year In Review(s?)

2012-12-25
Happy Holidays

2012-12-21
Welcome To A New Era!

2012-12-16
An Open Letter To United Health Care, Medcom, And The Medical Insurance Industry In General

2012-11-17
Whitehouse Petition To Remove "Under God" and "In God" From Currency And The Pledge.

2012-11-15
December 21, 2012

2012-11-11
If Hillary Clinton Ran For President, She Would Probably Be The Best-prepared Candidate In American History

2012-11-10
CIA Director David Petraeus Resigns After FBI Investigation Uncovers Affair With High-Profile Journalist

FIP Format Update

2012-11-07
Thank you for voting.

2012-11-06
Live Election Results

2012-09-30
FIP In Hiatus

2012-09-18
U.S.-Afghan Military Operations Suspended After Attacks

Iran Nuclear Chief Says IAEA Might Be Infiltrated By 'Terrorists And Saboteurs'

Romney Stands By Gaffe

2012-09-17
President Obama Says China Trade Practices Harm American Auto Parts Workers



Free Internet Press - News Aggregator
Updated every 10 minutes.
2016 Candidates Urge End to Violence in Baltimore
2015-04-28 14:16:47 (1 seconds ago) 
Declared and potential presidential candidates from both sides of the aisle are calling for an end to the violence in Baltimore, while acknowledging serious questions remain about how Freddie Gray died in police custody.






 
'Now they have a war': troops roll in to Baltimore as Obama urges US to start 'soul-searching'
2015-04-28 14:15:16 (2 minutes ago) 
City poised for military-enforced lockdown to prevent further riotingObama admits: ‘There are some police who aren’t doing the right thing’ Continue reading...
 
Security Council extends UN Western Sahara mission through April 2016
2015-04-28 14:12:23 (4 minutes ago) 
The Security Council today extended for another year the mandate of the United Nations mission tasked with monitoring the ceasefire in Western Sahara, known by the acronym MINURSO.
 
Elburn cop charged in sexual assault of girl over 10-year period
2015-04-28 14:11:48 (5 minutes ago) 
A longtime Elburn police officer has been charged with sexually assaulting a child over a decade, Kane County prosecutors said Tuesday.






 
How Well Do You Know the News?
2015-04-28 14:11:43 (5 minutes ago) 

Pew Research has a 12 question news quiz which compares your answers to those of the general public. Questions about politics proved particularly challenging.

The Fix: “The takeaway from all of this? Assuming — as lots and lots of people who either live in D.C. or follow politics closely do — that the average person is a deeply-informed consumer of political news is not even close to right. For most people, politics is something that almost never intersects with their daily lives and which they spend zero mind space on day in and day out.”

 
Florida House goes home 3 days early
2015-04-28 14:11:34 (5 minutes ago) 
TALLAHASSEE -- The Florida House went home three days early on Tuesday, with leaders citing the health-care expansion battle as the cause.
 
Marathon Survivor Adrianne Haslet-Davis Dances Across Finish Line on Prosthetic Leg
2015-04-28 14:11:31 (5 minutes ago) 
A survivor of the 2013 Boston Marathon bombings and former dance instructor who lost the lower half of her left leg danced across the finish line this morning.






 
Baltimore mayor criticized for police response to rioting
2015-04-28 14:11:22 (5 minutes ago) 
US-USA-POLICE-BALTIMORE:Baltimore mayor criticized for police response to rioting
 
Featherman: Nutter's disgraceful defense of the indefensible
2015-04-28 14:11:18 (6 minutes ago) 
Name any other leader in the United States who can justify giving urban terrorists the free reign to burn and loot a CVS and then burn a church senior center to the ground,
 
Saudis claim dozens of ISIS arrests, foiled plots
2015-04-28 14:11:11 (6 minutes ago) 
Government spokesman says it disrupted a plot for a suicide car bomber to attack the U.S. Embassy in Riyadh
 
North Dakota politician outed by Grindr user in retaliation for anti-gay vote
2015-04-28 14:10:55 (6 minutes ago) 

Representative Randy Boehning confirms he sent nude photos in question but says he voted against anti-discrimination bill over constitutional concerns

A North Dakota state representative says a Grindr user leaked nude pictures of him to the media in retaliation for his votes against gay rights, ending weeks of speculation in state political circles.

Representative Randy Boehning, a Republican who represents Fargo, told Fargo news site the Forum that he did indeed send photos, including one of his penis, to a man on Grindr who then leaked them to the media.

Continue reading...
 
How Spain's minimum marrying age compares with the rest of Europe
2015-04-28 14:10:55 (6 minutes ago) 

Spain is set to raise the minimum consenting age for marriage from 14 to 16. Currently it has one of the lowest minimum ages in the world

Continue reading...
 
Stop the sneering. If Ed Miliband’s best route to young voters is Russell Brand, so be it
2015-04-28 14:10:54 (6 minutes ago) 
The Labour leader is trying to reach a people who feel politics has little to offer them. And Brand has 10 million followers on Twitter Continue reading...
 
Tories accused of playing politics with Trident after defence debate
2015-04-28 14:10:52 (6 minutes ago) 

Defence secretary Michael Fallon refuses six times to confirm whether his party would vote to renew Britain’s nuclear deterrent under a Labour government

The Conservatives have been accused of playing politics with Britain’s nuclear deterrent after the defence secretary refused six times to confirm whether the Tories would vote to renew Trident under a Labour government.

Michael Fallon ran into trouble during a BBC2 debate when his Labour shadow, Vernon Coaker, challenged him about his claim that Ed Miliband would “barter away” Trident as part of a deal with the SNP to get into No 10.

Continue reading...
 
Limitations on Fines in Rental Agreements
2015-04-28 14:10:46 (6 minutes ago) 
Anyone who's scraped the last of their money together at the end of the month to pay rent has worried if they'll get fined for paying late. Same for those who've wondered about subletting or leaving their apartment before the lease expires. But are these fines or penalties legal?......
 
What Is a 'State of Emergency'?
2015-04-28 14:10:46 (6 minutes ago) 
The governor of Maryland has declared a state of emergency in Baltimore after protestors in the city clashed with police and others engaged in looting and extensive property damage on Monday. The night of violence followed the daytime funeral for Freddie Gray, a 25-year-old black man who died from......
 
EFF To Federal Circuit: Don’t Reward the Patent Troll that Lies in Wait
2015-04-28 14:10:38 (6 minutes ago) 

Suppose you get sued by a patent troll. You then learn that the troll has been sitting on its patent for years without giving you any warning. If you’d known about the risk, you might have been able to design your product differently to avoid infringement. Even worse, when you try to prove that the patent covers an obvious invention, all of the best evidence (such as websites or code repositories) has disappeared because of the passage of time. Instead of winning the case, you must pay years worth of damages to the troll.

The legal doctrine of “laches” is supposed to shield defendants from this scenario. If a plaintiff simply sleeps on his rights and as a result harms the ability of a defendant to defend himself, courts can refuse to enforce the plaintiff’s legal claim. (This is different from a statute of limitations, which sets a fixed time limit for bringing suit but does not consider whether the plaintiff delayed suit to the detriment of the defendant). Last week, together with Public Knowledge, EFF submitted an amicus brief arguing that laches should apply in patent cases.

The case is called SCA Hygiene v. First Quality Baby Products, and it relates to a patent on adult diapers, something EFF usually wouldn’t get involved in. But we did here because the Federal Circuit (the court that hears almost all patent appeals) will decide whether laches continue to apply in patent cases. The court is considering this question because last year the Supreme Court decided the copyright case Petrella v. MGM. In Petrella, the Supreme Court said that laches did not apply to copyright cases. So the question: based on Petrella, should laches continue to apply in patent cases?

We think laches should still be available, and here’s why: patent defendants and copyright defendants are in very different positions when it comes to defending against stale claims. Patent defendants, unlike their copyright counterparts, often defend themselves by showing that the patent owner’s claimed invention was obvious at the time of filing (thus making the patent invalid). But by delaying a lawsuit, a patent owner can make it difficult for the defendant to find what was known back when the application was filed; records get lost through the passage of time.

This is particularly important in the Internet era and with software patents. Traditionally, patent defendants would rely on other patents or journal articles to show that an invention was not new. In a world where innovation is routinely described in patents or journal articles, the passage of time may not be much of a worry: the USPTO or the library might have a copy of the work. But in the Internet age, where innovation occurs rapidly and often without any thought of patents or journals, the best proof that something was already known is often not easy to find. Websites are constantly rewritten. Software code gets lost or is not documented. For the patent defendant, without “laches” it could be possible to lose even though what the patent owner claimed was not actually new. Patent owners, absent laches, would be able to assert invalid patents with impunity.

Laches should exist in patent law, despite the Supreme Court’s decision in Petrella, because this is a place where patent law and copyright law differ. We hope the Federal Circuit recognizes the important differences between copyright law and patent law, and how patent owners, by delaying, seriously impact the ability of an innocent defendant to invalidate bad patents.

Files:  eff_amicus_sca_v_first_quality.pdfRelated Issues: PatentsPatent TrollsInnovation
Share this:   ||  Join EFF
 
Forest Hills investigation: Where are records?
2015-04-28 14:10:35 (6 minutes ago) 

It's been 8 business days since a reporter first sought documents on superintendent case.

        
 
Why New England Is Such a Hotbed for Skin Cancer
2015-04-28 14:10:33 (6 minutes ago) 
Why is a Boston city councilor pushing to give out sunscreen for free? That’s because Boston — and New England writ large — has some of the highest rates of skin cancer in the country.






 
VIDEO: Restaurant scoured for quake survivors
2015-04-28 14:10:31 (6 minutes ago) 
Rescuers in Nepal are still hopeful that they will find some survivors amongst the wreckage, although a lot of bodies are also being found.
 
Brothers died after 'dark web' drugs
2015-04-28 14:10:31 (6 minutes ago) 
Two brothers died after taking lethal doses of ecstasy which they had bought on the "dark web", an inquest is told.
 
Chicago transit agency blamed for airport train derailment
2015-04-28 14:10:30 (6 minutes ago) 
CHICAGO (AP) -- Chicago's transit agency shares in the blame for an accident last year in which a driver fell asleep and crashed a commuter train into a platform and up an escalator at O'Hare airport, federal investigators concluded Tuesday. And they warned that, without changes, a similar accident could happen elsewhere....
 
The bilingual Bush in Puerto Rico
2015-04-28 14:10:29 (6 minutes ago) 
SAN JUAN, Puerto Rico (AP) -- Jeb Bush confronted one of the Republican Party's touchiest debates head-on Tuesday, telling Puerto Ricans that conservatives should be proud that America is "an immigrant nation" and value the contribution immigrants make to the country....
 
You Will Be Surprised Who the Outside Agitators Really Are in Baltimore
2015-04-28 14:10:28 (6 minutes ago) 
The mayor of Baltimore was right to blame outsiders for causing trouble, but got it wrong.

On Monday, the country watched as a band of outside agitators descended on the streets of Baltimore, attacked locals with blunt force, intimidated innocent bystanders, and even threw rocks at native residents. Every day, these gun-toting rogues come from as far as New Jersey and Pennsylvania to intimidate the good people of Baltimore, forcing communities to cower under the threat of violence. The agitators are known for their menacing dark blue garb, hostile behavior and gangland-style codes of secrecy and silence. Though many of these ruffians have attempted to conceal their identities from their victims, they can be easily spotted by the badges that signify membership in the widely feared Baltimore Police Department.

According to data posted on the city of Baltimore’s OpenBaltimore website in 2012, over 70 percent of Baltimore Police Department officers live outside city limits, with at least 10 percent living over state lines, in places as far away as New Jersey and Pennsylvania. By contrast, almost all of those arrested in ongoing protests sparked by the police killing of the unarmed Baltimorean Freddie Gray reside firmly within the city. These facts were apparently lost on Baltimore Mayor Stephanie Rawlings-Blake when she blamed “outside forces” for all the looting of local businesses and attacks on cops. Similarly, the Baltimore Police Department claimed that "outside agitators continue to be the instigators behind acts of violence and destruction,” even as it conceded in the same statement that “the vast majority of arrests reflect local residency.” No evidence of outside agitation was produced by the mayor or the police, and none was demanded by much of the media covering the ongoing troubles.

This week’s scenes of mostly white cops battling the African-American youth of Baltimore captured a legacy of deeply entrenched racism that stretches back to Maryland’s Antebellum days. Though Maryland ended the slave trade in 1783, over 40,000 slaves remained in bondage in its Eastern Shore, near the border of Virginia, until Emancipation Day. When the Sixth Massachusetts Militia marched through Baltimore on April 19, 1861 on its way to protect Washington DC from advancing Confederate forces, the Union troops were attacked in the center of town with rocks, bricks and even pistols by local Southern sympathizers. Maryland’s last recorded lynching of a black man occurred in the town of Princess Anne on the Eastern Shore in 1933, when a thousand whites dragged assault suspect George Armwood from his jail cell, tortured him, hacked his ear off and hung him from a tree. It was the 33rd documented lynching in the state since 1882.

Gerald Horne, a professor of history and African American Studies at the University of Houston, sees the legacy of slavery as an underlying factor in the policing of majority black cities like Baltimore. “The origins of the urban police department lies precisely in slavery,” Horne remarked in a recent interview with The Real News founder Paul Jay. “That is to say, slave patrols that were designated to interrogate, to investigate Africans who were out and about without any kind of investigation. You fast forward to 2015 and you still see more than remnants of that particular system.”

The Gilmore Homes area where Freddie Gray was violently apprehended and later killed by Baltimore police officers is one of the city’s most heavily policed areas. Eddie Conway, a local civil rights activist who served 43 years in prison after a dubious conviction for killing two cops, explained in an interview with Democracy Now! that Gilmore Homes is “a ‘broken windows’ police area in which people and residents in that area are arrested for sitting on their own steps. They are loitering in their own community, on their own steps, and they're harassed constantly.”

“[Cops] won’t let us go nowhere,” one young Gilmore Homes resident complained to The Real News, “They’ll tell us, ‘Move, we gotta go here, you gotta move off there.’ We ain’t doing nothing!”

When Paul Jay relocated The Real News operations to Baltimore in 2013 and initiated a series of roundtable discussions with local cops, he learned about the hostile racial attitudes white officers were importing into the city. “I’ve talked to some black cops in Baltimore and one of them told me that in the locker room,” Jay said, “and when they’re getting ready to go on their shift, some of the white cops joke…’Time to go back to work in the zoo.’”

While the Baltimore Police Department recruits its manpower outside city limits, its leadership is regularly junketed to training tours in Israel, the occupying power whose hyper-militarized settlers act as some of the Middle East’s most aggressive outside agitators. In September 2009, members of the Baltimore PD “toured [Israel] and met with their Israeli counterparts to exchange information relating to best practices and recent advancements in security and counterterrorism,” according to the trip’s sponsor, Project Interchange. A separate Israel tour organized by the neoconservative Jewish Institute for National Security saw members of the Baltimore PD “begin the process of sharing ‘lessons learned’ in Israel with their law enforcement colleagues in the United States.”

Back in Maryland, the rate of citizens killed by police officers is skyrocketing. A report by the ACLU has found that 109 people died after encounters with Maryland police between 2010 and 2014, that almost 70 percent of those who died were black, and that over 40 percent of them were unarmed. In Baltimore alone, the city was forced to pay $5.7 million in lawsuits by suspects who accused police officers of beating them brutally and without cause.

Even after the National Guard vacates the streets of Baltimore and the state of emergency is lifted, vast swaths of the city will remain under occupation. Rather than return to a deadly status quo, the city could start answering the crisis by enacting residential requirements that force police officers to live in the neighborhoods they patrol.

Outside agitators have caused enough trouble in Baltimore. It’s time to send them back where they came from.

 Related Stories5 Things Everyone Needs to Know About Baltimore15 Personal Insults That Brought Same-Sex Marriage To The Supreme CourtBaltimore Orioles Executive Issues Surprising Defense of Protesters' Right to Be Outraged About Freddie Gray and Economy
 
40 years later, Vietnam still deeply divided over war
2015-04-28 14:01:08 (16 minutes ago) 

Divisions over a war that cost 3 million Vietnamese lives still haven't been addressed.

        
 
Read and listen: Supreme Court oral arguments on gay marriage
2015-04-28 14:01:07 (16 minutes ago) 

Audio recordings and transcripts from today's oral arguments on same-sex marriage.

       
 
Cecile Richards: We Need to Talk—Really Talk—About Abortion
2015-04-28 14:00:36 (16 minutes ago) 
A
 
Robert Downey Jr calls British journalist 'bottom-feeding muckraker'
2015-04-28 14:00:32 (16 minutes ago) 

The actor who walked out of an interview with Krishnan Guru-Murthy said he was being ‘scrutinised like a kiddie-fiddler who’s running for mayor’

Robert Downey Jr has spoken for the first time about walking out of an interview with British journalist Krishnan Guru-Murthy, calling the Channel 4 News reporter a “bottom-feeding muckraker”.

Speaking to US radio host Howard Stern, Downey Jr professed himself unrepentant about the incident, saying “I just wish I’d left sooner.”

Continue reading...
 
Jeb Bush pushes for Puerto Rico statehood
2015-04-28 14:00:18 (17 minutes ago) 
Jeb Bush reiterated his support for Puerto Rico statehood on Tuesday, telling a crowd that he's long been a supporter of the movement to make the U.S. territory the 51st state.
 
Tipsarevic beats Tomic in 3 sets at BMW Open in Munich
2015-04-28 14:00:13 (17 minutes ago) 

MUNICH — Wild-card entry Janko Tipsarevic rallied to beat sixth-seeded Bernard Tomic 5-7, 6-1, 7-6 (3) in the first round of the BMW Open clay-court tournament on Tuesday.

Tipsarevic, once ranked No. 8 in the world, is making a comeback after being sidelined 17 months following two surgeries to remove a benign tumor from his left foot.

After the start of play was delayed for several hours because of rain, Tipsarevic overcame cool conditions to win in just over two hours. He served 11 aces to Tomic's 5.

 
Obama calls for national 'soul searching' over Freddie Gray's death
2015-04-28 14:00:05 (17 minutes ago) 
WASHINGTON -- President Barack Obama on Tuesday criticized those rioting in the streets of Baltimore as "criminals" and "thugs" and argued that broader societal changes are needed to address underlying tensions that exist between African American communities and the police.
 
Gross Cystic Disease Fluid Protein 15 in Stratum Corneum Is a Potential Marker of Decreased Eccrine Sweating for Atopic Dermatitis
2015-04-28 13:58:33 (18 minutes ago) 

by Koji Kamiya, Jun-Ichi Sakabe, Hayato Yamaguchi, Takahiro Suzuki, Tsuyoshi Yatagai, Masahiro Aoshima, Taisuke Ito, Yoshiki Tokura

It is well known that eccrine sweating is attenuated in patients with atopic dermatitis (AD). We have reported by using proteome analysis that gross cystic disease fluid protein 15 (GCDFP15), a substance secreted from eccrine sweat glands, is decreased in tape-stripped stratum corneum (SC) samples from AD patients. The aim of this study was to evaluate GCDFP15 production by eccrine glands with SC samples and to assess sweating in AD. SC samples were obtained from 51 healthy control (HC) and 51 AD individuals. Sweat samples were from 18 HC and 12 AD subjects. GCDFP15 was quantified by ELISA. By immunohistochemistry, the expression of GCDFP15 in eccrine glands was examined in normal and AD skin specimens. To identify GCDFP15-producing cells, double immunofluorescence staining for GCDFP15 and S100 protein was performed in frozen sections. To address the mechanism underlying the decreased eccrine sweating in AD patients, we examined the expression of cholinergic receptor M3 (CHRM3), a receptor for acetylcholine-induced sweating, in eccrine sweat glands. The amounts of GCDFP15 in the SC extracts were significantly lower in AD than HC (P < 0.0001). The sweat samples from AD patients also had lower levels of GCDFP15 concentration (P < 0.05). Immunohistochemistry showed positive GCDFP15 staining in the eccrine gland secretory cells and the ductal and acrosyringial lumen in normal skin, but AD lacked clear staining. Immunofluorescence staining revealed that GCDFP15 was co-expressed with S100 protein, suggesting that the clear cell of eccrine glands produces GCDFP15. Finally, we found that the expression of CHRM3 was depressed in AD, suggesting contribution to the low sweating. The SC of AD patients contains a low amount of GCDFP15 due to both low sweating and low GCDFP15 concentration in the sweat. GCDFP15 in SC is a potential marker for dysregulated sweating in AD.
 
Sandwiches Are a Major Contributor to Dietary Sodium Intake
2015-04-28 13:53:53 (23 minutes ago) 
Sandwiches account for one-fifth of total sodium intake, with nearly half of American adults consuming them on any given day, according to new study published in the Journal of the Academy of Nutrition and Dietetics
 
In Puerto Rico, Jeb Bush pushes statehood
2015-04-28 13:52:49 (24 minutes ago) 
 
Burundi: Ban condemns election-related violence after President nominated as candidate
2015-04-28 13:51:46 (25 minutes ago) 
United Nations Secretary-General Ban Ki-moon has today condemned the outbreak of violence in Burundi following the nomination of President Pierre Nkurunziza as the presidential candidate of the country’s ruling party, and appealed to all Burundians to “safeguard the hard won gains” made in peace and democracy.
 
Cincinnati restaurant sorry for 'insensitive' Bruce Jenner hot dog name
2015-04-28 13:51:37 (25 minutes ago) 
CINCINNATI (AP) — The owner of a popular Cincinnati restaurant has apologized after being criticized by transgender advocates for naming its hot dog of the day the "Bruce Jenner 2.0."
 
Swedish top court allows Assange to appeal detention order
2015-04-28 13:51:35 (25 minutes ago) 

HELSINKI — Sweden's highest court decided Tuesday to allow Julian Assange to appeal a detention order against the WikiLeaks founder over allegations of sex crimes.

The Swedish Supreme Court said it has "granted leave to appeal the issue of detention." It gave no reason for the decision.

 
Marathon Survivor Adrianne Haslet-Davis Dances Across Finish Line on Prosthetic Leg
2015-04-28 13:51:33 (25 minutes ago) 
A survivor of the 2013 Boston Marathon bombings and former dance instructor who lost the lower half of her left leg danced across the finish line this morning.






 
This Pacoima gang hit killed a family's patriarchs. The killers were never caught
2015-04-28 13:51:25 (25 minutes ago) 

On a cool Sunday evening long after Easter sunrise services, two men slipped into a Pacoima backyard a decade ago and gunned down the brothers Villareal.

Juan Dedios Villareal, who owned the home, was 34; his brother Robert was 29. Both had good jobs. Both were great husbands and dads, according to their families.

 
Analysis of Binary Multivariate Longitudinal Data via 2-Dimensional Orbits: An Application to the Agincourt Health and Socio-Demographic Surveillance System in South Africa
2015-04-28 13:51:21 (25 minutes ago) 

by Maria Vivien Visaya, David Sherwell, Benn Sartorius, Fabien Cromieres

We analyse demographic longitudinal survey data of South African (SA) and Mozambican (MOZ) rural households from the Agincourt Health and Socio-Demographic Surveillance System in South Africa. In particular, we determine whether absolute poverty status (APS) is associated with selected household variables pertaining to socio-economic determination, namely household head age, household size, cumulative death, adults to minor ratio, and influx. For comparative purposes, households are classified according to household head nationality (SA or MOZ) and APS (rich or poor). The longitudinal data of each of the four subpopulations (SA rich, SA poor, MOZ rich, and MOZ poor) is a five-dimensional space defined by binary variables (questions), subjects, and time. We use the orbit method to represent binary multivariate longitudinal data (BMLD) of each household as a two-dimensional orbit and to visualise dynamics and behaviour of the population. At each time step, a point (x, y) from the orbit of a household corresponds to the observation of the household, where x is a binary sequence of responses and y is an ordering of variables. The ordering of variables is dynamically rearranged such that clusters and holes associated to least and frequently changing variables in the state space respectively, are exposed. Analysis of orbits reveals information of change at both individual- and population-level, change patterns in the data, capacity of states in the state space, and density of state transitions in the orbits. Analysis of household orbits of the four subpopulations show association between (i) households headed by older adults and rich households, (ii) large household size and poor households, and (iii) households with more minors than adults and poor households. Our results are compared to other methods of BMLD analysis.
 
Cholesteryl Esters Are Elevated in the Lipid Fraction of Bronchoalveolar Lavage Fluid Collected from Pediatric Cystic Fibrosis Patients
2015-04-28 13:51:21 (25 minutes ago) 

by Daniel C. Ma, Alexander J. Yoon, Kym F. Faull, Robert Desharnais, Edith T. Zemanick, Edith Porter

Background

Host-derived lipids including cholesteryl esters (CEs) such as cholesteryl linoleate have emerged as important antibacterial effectors of innate immunity in the airways and cholesteryl linoleate has been found elevated in the context of inflammation. Cystic fibrosis (CF) patients suffer from chronic infection and severe inflammation in the airways. Here, we identified and quantified CEs in bronchoalveolar lavage fluid (BALF) from CF patients and non-CF disease controls, and tested whether CE concentrations are linked to the disease.

Materials and Methods

CEs in BALF from 6 pediatric subjects with CF and 7 pediatric subjects with non-CF chronic lung disease were quantified by mass spectral analysis using liquid chromatography coupled with tandem mass spectrometry and multiple reaction monitoring. BALFs were also examined for total lipid, total protein, albumin, and, as a marker for inflammation, human neutrophil peptide (HNP) 1–3 concentrations. Statistical analysis was conducted after log 10 transformation of the data.

Results

Total lipid/protein ratio was reduced in CF BALF (p = 0.018) but the concentrations of CEs, including cholesteryl linoleate, were elevated in the total lipid fraction in CF BALF compared to non-CF disease controls (p < 0.050). In addition, the concentrations of CEs and HNP1-3 correlated with one another (p < 0.050).

Conclusions

The data suggests that the lipid composition of BALF is altered in CF with less total lipid relative to protein but with increased CE concentrations in the lipid fraction, likely contributed by inflammation. Future longitudinal studies may reveal the suitability of CEs as a novel biomarker for CF disease activity which may provide new information on the lipid mediated pathophysiology of the disease.

 
Prognostic Significance of Matrix Metalloproteinase-7 in Gastric Cancer Survival: A Meta-Analysis
2015-04-28 13:51:21 (25 minutes ago) 

by Saeed Soleyman-Jahi, Saharnaz Nedjat, Afshin Abdirad, Niloofar Hoorshad, Reza Heidari, Kazem Zendehdel

The prognostic role of matrix metalloproteinase-7 in gastric cancer survival has been widely evaluated. However, the results are controversial. We aimed to set up a meta-analysis to reach a conclusion on the prognostic significance of metalloproteinase-7 in gastric cancer survival as well as its association with clinicopathological parameters. We searched popular databases from 1988 until October 2014 to gather eligible peer-reviewed papers addressing the prognostic effect of matrix metalloproteinase-7 in gastric cancer patients' survival. The CASP check list was used for quality appraisal. Pooled hazard ratio (HR) for survival and odds ratio (OR) for association with their 95% confidence interval (CI) were considered as summary measurements. Finally, 1208 gastric cancer patients from nine studies were included in the meta-analysis. Pooled HR estimate for survival was 2.01 (95% CI = 1.62 – 2.50, P < 0.001), which indicated a significant poor prognostic effect for matrix metalloproteinase-7. Sensitivity analysis detected no dominancy for any study. No publication bias was detected according to Egger’s and Begg’s tests. Clinicopathological assessment revealed that higher matrix metalloproteinase-7 expression is associated with deeper invasion (pooled OR = 3.20; 95% CI = 1.14 – 8.96; P = 0.026), higher TNM stage (pooled OR = 3.67; 95% CI = 2.281-5.99; P
 
Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004
2015-04-28 13:51:21 (25 minutes ago) 

by David S. Lopez, Run Wang, Konstantinos K. Tsilidis, Huirong Zhu, Carrie R. Daniel, Arup Sinha, Steven Canfield

Objectives

Caffeine is consumed by more than 85% of adults and little is known about its role on erectile dysfunction (ED) in population-based studies. We investigated the association of caffeine intake and caffeinated beverages with ED, and whether these associations vary among comorbidities for ED.

Material and Method

Data were analyzed for 3724 men (≥20 years old) who participated in the National Health and Nutrition Examination Survey (NHANES). ED was assessed by a single question during a self-paced, computer-assisted self-interview. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable logistic regression analyses using appropriate sampling weights were conducted.

Results

We found that men in the 3rd (85-170 mg/day) and 4th (171-303 mg/day) quintiles of caffeine intake were less likely to report ED compared to men in the lowest 1st quintile (0-7 mg/day) [OR: 0.58; 95% CI, 0.37–0.89; and OR: 0.61; 95% CI, 0.38–0.97, respectively], but no evidence for a trend. Similarly, among overweight/obese and hypertensive men, there was an inverse association between higher quintiles of caffeine intake and ED compared to men in the lowest 1st quintile, P≤0.05 for each quintile. However, only among men without diabetes we found a similar inverse association (Ptrend = 0.01).

Conclusion

Caffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day). This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Yet, these associations are warranted to be investigated in prospective studies.

 
Approximate Joint Diagonalization and Geometric Mean of Symmetric Positive Definite Matrices
2015-04-28 13:51:21 (25 minutes ago) 

by Marco Congedo, Bijan Afsari, Alexandre Barachant, Maher Moakher

We explore the connection between two problems that have arisen independently in the signal processing and related fields: the estimation of the geometric mean of a set of symmetric positive definite (SPD) matrices and their approximate joint diagonalization (AJD). Today there is a considerable interest in estimating the geometric mean of a SPD matrix set in the manifold of SPD matrices endowed with the Fisher information metric. The resulting mean has several important invariance properties and has proven very useful in diverse engineering applications such as biomedical and image data processing. While for two SPD matrices the mean has an algebraic closed form solution, for a set of more than two SPD matrices it can only be estimated by iterative algorithms. However, none of the existing iterative algorithms feature at the same time fast convergence, low computational complexity per iteration and guarantee of convergence. For this reason, recently other definitions of geometric mean based on symmetric divergence measures, such as the Bhattacharyya divergence, have been considered. The resulting means, although possibly useful in practice, do not satisfy all desirable invariance properties. In this paper we consider geometric means of covariance matrices estimated on high-dimensional time-series, assuming that the data is generated according to an instantaneous mixing model, which is very common in signal processing. We show that in these circumstances we can approximate the Fisher information geometric mean by employing an efficient AJD algorithm. Our approximation is in general much closer to the Fisher information geometric mean as compared to its competitors and verifies many invariance properties. Furthermore, convergence is guaranteed, the computational complexity is low and the convergence rate is quadratic. The accuracy of this new geometric mean approximation is demonstrated by means of simulations.
 
Preemption versus Entrenchment: Towards a Construction-General Solution to the Problem of the Retreat from Verb Argument Structure Overgeneralization
2015-04-28 13:51:21 (25 minutes ago) 

by Ben Ambridge, Amy Bidgood, Katherine E. Twomey, Julian M. Pine, Caroline F. Rowland, Daniel Freudenthal

Participants aged 5;2-6;8, 9;2-10;6 and 18;1-22;2 (72 at each age) rated verb argument structure overgeneralization errors (e.g., *Daddy giggled the baby) using a five-point scale. The study was designed to investigate the feasibility of two proposed construction-general solutions to the question of how children retreat from, or avoid, such errors. No support was found for the prediction of the preemption hypothesis that the greater the frequency of the verb in the single most nearly synonymous construction (for this example, the periphrastic causative; e.g., Daddy made the baby giggle), the lower the acceptability of the error. Support was found, however, for the prediction of the entrenchment hypothesis that the greater the overall frequency of the verb, regardless of construction, the lower the acceptability of the error, at least for the two older groups. Thus while entrenchment appears to be a robust solution to the problem of the retreat from error, and one that generalizes across different error types, we did not find evidence that this is the case for preemption. The implication is that the solution to the retreat from error lies not with specialized mechanisms, but rather in a probabilistic process of construction competition.
 
Proteomic Analysis of Copper-Binding Proteins in Excess Copper-Stressed Roots of Two Rice (Oryza sativa L.) Varieties with Different Cu Tolerances
2015-04-28 13:51:21 (25 minutes ago) 

by Chen Chen, Yufeng Song, Kai Zhuang, Lu Li, Yan Xia, Zhenguo Shen

To better understand the mechanisms involved in the heavy metal stress response and tolerance in plants, a proteomic approach was used to investigate the differences in Cu-binding protein expression in Cu-tolerant and Cu-sensitive rice varieties. Cu-binding proteins from Cu-treated rice roots were separated using a new IMAC method in which an IDA-sepharose column was applied prior to the Cu-IMAC column to remove metal ions from protein samples. More than 300 protein spots were reproducibly detected in the 2D gel. Thirty-five protein spots exhibited changes greater than 1.5-fold in intensity compared to the control. Twenty-four proteins contained one or more of nine putative metal-binding motifs reported by Smith et al., and 19 proteins (spots) contained one to three of the top six motifs reported by Kung et al. The intensities of seven protein spots were increased in the Cu-tolerant variety B1139 compared to the Cu-sensitive variety B1195 (p
 
Op-Docs: ‘Rent-a-Foreigner in China’
2015-04-28 13:51:19 (25 minutes ago) 
In this short documentary, housing developers in China hire ordinary foreigners to pose as celebrities to raise flagging property sales.
 
Auschwitz survivor: Trial of ex-Nazi guard is 'satisfaction'
2015-04-28 13:51:14 (26 minutes ago) 
BERLIN (AP) - An Auschwitz survivor who lost 49 family members in the Holocaust says the fact that a 93-year-old former guard at the death camp is on trial is more important than any punishment.
 
Drone Video Captures 'Broken City' of Kathmandu
2015-04-28 13:51:10 (26 minutes ago) 
NBC News' Miguel Almaguer discusses drone video capturing a bird's-eye view of destroyed temples in Kathmandu.
 
Kevin McCarthy: Obama's demands would ruin attempt to lift sequester
2015-04-28 13:51:06 (26 minutes ago) 

House Majority Leader Kevin McCarthy said Tuesday that Republicans will not try to lift "sequester" limits during the annual spending process because the caps are written into law and they view President Obama as an uncooperative negotiator.

Mr. McCarthy, California Republican, argued Mr. Obama would seek tax hikes to get ...

 
Behind the Storefront: The case for buying Container Store as shares trade below IPO price
2015-04-28 14:16:24 (24 seconds ago) 
The Container Store Group Inc. stock slumped up to 24% on Tuesday to trade below its 2013 IPO price of $18, but some analysts still believe in the company.
 
Sandwiches Are a Major Contributor to Dietary Sodium Intake
2015-04-28 14:13:55 (3 minutes ago) 
Sandwiches account for one-fifth of total sodium intake, with nearly half of American adults consuming them on any given day, according to new study published in the Journal of the Academy of Nutrition and Dietetics
 
ICANN wants total control of DNS while breaking its own bylaws to block .africa probe
2015-04-28 14:12:21 (4 minutes ago) 
 
Blackhawks open series vs. Wild on Friday
2015-04-28 14:11:48 (5 minutes ago) 
The Chicago Blackhawks and Minnesota Wild finally know when they will hit the ice for their second-round series.






 
Coast Guard suspends search for missing Hawaii fisherman who survived previous ordeal at sea
2015-04-28 14:11:43 (5 minutes ago) 
 
[Image]Why people give up
2015-04-28 14:11:33 (5 minutes ago) 
submitted by StarGate23 to GetMotivated
[link] [43 comments]
 
Review: ‘Carousel,’ a Broadway Turn at Lyric Opera of Chicago
2015-04-28 14:11:26 (5 minutes ago) 
This darkest of the major musicals by Richard Rodgers and Oscar Hammerstein II fits quite snugly into even the most doom-ridden opera season.
 
Baltimore mayor criticized for police response to rioting
2015-04-28 14:11:21 (5 minutes ago) 
US-USA-POLICE-BALTIMORE:Baltimore mayor criticized for police response to rioting
 
'They're Stealing': Obama Speaks Out on Baltimore Rioters
2015-04-28 14:11:17 (6 minutes ago) 
President Obama sounds off on a recent wave of incidents involving force by police in communities across America.
 
The Wall Street Journal: Cablevision to offer Hulu to its customers
2015-04-28 14:11:09 (6 minutes ago) 
Cable provider has been targeting viewers who are looking to ‘cut the cord’.
 
We must not turn a blind eye: these desperate migrants deserve compassion
2015-04-28 14:10:55 (6 minutes ago) 

Like the bishop of Manchester (Opinion, theguardian.com, 25 April), I too “want leaders who look on migrants with compassion”, and I too am horrified to read that a columnist in one newspaper described migrants as “cockroaches”, echoing, horribly, the sort of language used by the Nazis of the Jews. But I want more. I want Britain to play its proper part as leaders in Europe in helping to resolve this crisis, and putting an end to the deaths, particularly of children. If that means us taking some migrants in, along with other European countries, so be it – that may well be the right thing to do. And politicians cannot, with any vestige of moral sensitivity, say that it is not, or that they will not take them, until all options about how to help these desperate and terrified people have been explored.

I also want to hear less about the wrongs done by people traffickers, terrible though much of that is, and more understanding of why people are so desperate to come. I want our leaders to explain that, if you fear beheading by Isis because you are a Christian, you are likely to take extreme measures to escape. And I want our leaders to show some sympathy and take some responsibility, and tell the nation that some of these crises may have been made worse by some of the UK’s own interventions, however well intentioned they once were.

Continue reading...
 
Greek finance minister denies being sidelined at debt talks
2015-04-28 14:10:55 (6 minutes ago) 

Yanis Varoufakis renews outspoken attack on eurozone partners despite being replaced as leader of bailout negotiating team

Continue reading...
 
Tories accused of playing politics with Trident after defence debate
2015-04-28 14:10:54 (6 minutes ago) 

Defence secretary Michael Fallon refuses six times to confirm whether his party would vote to renew Britain’s nuclear deterrent under a Labour government

Continue reading...
 
Area Media Reporter Unable to Coherently Align Analysis With Reporting
2015-04-28 14:10:48 (6 minutes ago) 

MSNBC’s Morning Joe, a largely unwatched showcase for a former congressman’s enormous ego, is (still) in serious ratings trouble, according to The Politico media reporter Dylan Byers:

Read more...








 
'The Good Wife': Good Law? -- Season 6, Episode 20
2015-04-28 14:10:46 (6 minutes ago) 
RD is back with another legal issue to tackle. Kalinda and Cary fall over themselves to testify against Lemond Bishop. After her downfall, Alicia is returning to the firm, or is she? Here's what you need to know from last night's episode, entitled "The Deconstruction":......
 
Sixty Percent of Americans Not Practicing for Disaster: FEMA urges everyone to prepare by participating in National PrepareAthon! Day on April 30
2015-04-28 14:10:46 (6 minutes ago) 

WASHINGTON – A recent Federal Emergency Management Agency (FEMA) survey found that nearly 60 percent of American adults have not practiced what to do in a disaster by participating in a disaster drill or preparedness exercise at work, school, or home in the past year. Further, only 39 percent of respondents have developed an emergency plan and discussed it with their household.

Language English
 
National Football League to voluntarily give up tax-exempt status
2015-04-28 14:10:38 (6 minutes ago) 
Tired of the "distraction," the NFL is moving on. Two years ago, we began to loudly question why the National Football League had a "non-profit" status. Daily Kos launched a petition gathered nearly 350,000 signatures and the story has continued to grow.

Today the NFL has made a surprising announcement:

In a letter to team owners, Commissioner Roger Goodell says the league office and its management council will file tax returns as taxable entities for the 2015 fiscal year. Goodell says the NFL has been tax-exempt since 1942, though all 32 teams pay taxes on their income.

Goodell says the change will not alter the function or operation of the league, since all the teams already pay taxes.

Some members of Congress have criticized the NFL, which generates billions in revenue, for being tax-exempt. Goodell says the status has become a "distraction."

Congrats to you, the Daily Kos readers who took action and kept up the pressure on Congress and the NFL.
 
What happened to the city's little leaguers?
2015-04-28 14:10:35 (6 minutes ago) 

Cincinnati, where 84 little leaguers aren't sure how they're getting to the game next week.

        
 
“I’m Very Pissed”: Vietnam Vet Stands Up Against Baltimore Rioters
2015-04-28 14:10:33 (6 minutes ago) 
CNN interviewed Robert Valentine, who was witnessing the unrest and telling young rioters to stop.






 
Flash crash trader to face court again
2015-04-28 14:10:31 (6 minutes ago) 
A UK financial trader accused of contributing to the 2010 Wall Street "flash crash" is due to appear in court again on Wednesday.
 
Flash crash trader to face court again
2015-04-28 14:10:31 (6 minutes ago) 
A UK financial trader accused of contributing to the 2010 Wall Street "flash crash" is due to appear in court again on Wednesday.
 
The bilingual Bush in Puerto Rico
2015-04-28 14:10:30 (6 minutes ago) 
SAN JUAN, Puerto Rico (AP) -- Jeb Bush confronted one of the Republican Party's touchiest debates head-on Tuesday, telling Puerto Ricans that conservatives should be proud that America is "an immigrant nation" and value the contribution immigrants make to the country....
 
The bilingual Bush in Puerto Rico
2015-04-28 14:10:28 (6 minutes ago) 
SAN JUAN, Puerto Rico (AP) -- Jeb Bush confronted one of the Republican Party's touchiest debates head-on Tuesday, telling Puerto Ricans that conservatives should be proud that America is "an immigrant nation" and value the contribution immigrants make to the country....
 
Sri Lanka's Parliament Clips Presidential Powers
2015-04-28 14:10:04 (7 minutes ago) 
Sri Lanka's Parliament votes overwhelmingly to clip extensive presidential powers
 
Saudi Arabia foils U.S. Embassy attack, arrests 93 suspects
2015-04-28 14:01:07 (16 minutes ago) 

The suspects had ties to the Islamic State and were planning multi-pronged attacks, Saudi Arabia says.

       
 
40 years later, Vietnam still deeply divided over war
2015-04-28 14:01:06 (16 minutes ago) 

Divisions over a war that cost 3 million Vietnamese lives still haven't been addressed.

       
 
See Baltimore Dig Out From the Ashes as National Guard Arrives
2015-04-28 14:00:36 (16 minutes ago) 
A
 
Sandwiches Are a Major Contributor to Dietary Sodium Intake
2015-04-28 14:00:24 (16 minutes ago) 
Sandwiches account for one-fifth of total sodium intake, with nearly half of American adults consuming them on any given day, according to new study published in the Journal of the Academy of Nutrition and Dietetics
 
Blackhawks open series vs. Wild on Friday
2015-04-28 14:00:17 (17 minutes ago) 
The Chicago Blackhawks and Minnesota Wild finally know when they will hit the ice for their second-round series.






 
Rare Robert Redford family reunion at Chaplin Awards
2015-04-28 14:00:13 (17 minutes ago) 

NEW YORK — Robert Redford says getting his entire family in one place at one time can be a challenge.

"We don't come together that easy," the actor said at the Film Society of Lincoln Center Chaplin Award ceremony, where he was honored with the prestigious prize as his wife, three children, their spouses and lots of grandkids looked on.

"It's the only time I can get everybody together," the 78-year-old actor said ahead of the Monday night affair. "All of them coming here was a shock, but a wonderful shock."

 
Watch: President Obama Condemns Violence in Baltimore
2015-04-28 14:00:01 (17 minutes ago) 
The president said there is "no excuse" for the violence, looting and arson that followed the funeral for Freddie Gray.
 
The Tell: An Apple cash spinoff would be the 17th biggest S&P company
2015-04-28 13:56:21 (20 minutes ago) 
Apple’s total cash hoard comes to about $194 billion. That sounds like a huge number on its own, but it’s even more stunning when put in relative terms. Bespoke did just that with this chart.
 
Bono Fast Facts
2015-04-28 13:52:49 (24 minutes ago) 
 
Lockheed’s New Drone Will Help Rescuers Find Missing People
2015-04-28 13:51:50 (25 minutes ago) 

Lockheed is working to help locate people with cognitive disabilities that make them prone to wandering.

The post Lockheed’s New Drone Will Help Rescuers Find Missing People appeared first on WIRED.








 
DNA-testing dog poo? You’d have to be Barking!
2015-04-28 13:51:41 (25 minutes ago) 
One east London council is to introduce technology that will enable it to trace ownwers who allow their dogs to foul the borough. And it could be coming to an area near you soon

Keep your eyes open for dog mess if you are walking in the London borough of Barking & Dagenham. Do not tread on it. That mess is evidence. Soon someone will be along with a little sample pot to scoop up a thimbleful and take it off to the lab. And when, in several months’ or years’ time, the 18,000 dogs of the borough have all registered their DNA, the owner of the dog who left that mess will be brought to justice.

Barking & Dagenham is the first UK council to use DNA testing to catch dog owners who fail to clear up their pet’s waste. “When a council with the name of Barking asked, you couldn’t ask for a better location,” says Gary Downie, the managing director of Streetkleen, the company that has obtained exclusive licensing rights to the DNA-testing technology. (Streetkleen previously made the news in 2013 with its idea to convert dog waste into renewable energy.)

Continue reading...
 
Florida lawmakers vote for limits on drones
2015-04-28 13:51:37 (25 minutes ago) 
TALLAHASSEE — Using drones to take photos of people on their own property could soon be illegal in Florida.
 
Wisconsin Democrat wants to raise state's minimum wage to $15 an hour
2015-04-28 13:51:35 (25 minutes ago) 
 
Russian Cargo Ship Spinning Out of Control in Orbit [Video]
2015-04-28 13:51:31 (25 minutes ago) 
The uncrewed ship malfunctioned shortly after launching on a mission to the International Space Station. Ground controllers are working to salvage the mission

-- Read more on ScientificAmerican.com
 
Marathon Survivor Adrianne Haslet-Davis Dances Across Finish Line on Prosthetic Leg
2015-04-28 13:51:24 (25 minutes ago) 
A survivor of the 2013 Boston Marathon bombings and former dance instructor who lost the lower half of her left leg danced across the finish line this morning.






 
Surface Modification and Characterisation of Silk Fibroin Fabric Produced by the Layer-by-Layer Self-Assembly of Multilayer Alginate/Regenerated Silk Fibroin
2015-04-28 13:51:21 (25 minutes ago) 

by Gaotian Shen, Xingyou Hu, Guoping Guan, Lu Wang

Silk-based medical products have a long history of use as a material for surgical sutures because of their desirable mechanical properties. However, silk fibroin fabric has been reported to be haemolytic when in direct contact with blood. The layer-by-layer self-assembly technique provides a method for surface modification to improve the biocompatibility of silk fibroin fabrics. Regenerated silk fibroin and alginate, which have excellent biocompatibility and low immunogenicity, are outstanding candidates for polyelectrolyte deposition. In this study, silk fabric was degummed and positively charged to create a silk fibroin fabric that could undergo self-assembly. The multilayer self-assembly of the silk fibroin fabric was achieved by alternating the polyelectrolyte deposition of a negatively charged alginate solution (pH = 8) and a positively charged regenerated silk fibroin solution (pH = 2). Finally, the negatively charged regenerated silk fibroin solution (pH = 8) was used to assemble the outermost layer of the fabric so that the surface would be negatively charged. A stable structural transition was induced using 75% ethanol. The thickness and morphology were characterised using atomic force microscopy. The properties of the self-assembled silk fibroin fabric, such as the bursting strength, thermal stability and flushing stability, indicated that the fabric was stable. In addition, the cytocompatibility and haemocompatibility of the self-assembled silk fibroin fabrics were evaluated. The results indicated that the biocompatibility of the self-assembled multilayers was acceptable and that it improved markedly. In particular, after the self-assembly, the fabric was able to prevent platelet adhesion. Furthermore, other non-haemolytic biomaterials can be created through self-assembly of more than 1.5 bilayers, and we propose that self-assembled silk fibroin fabric may be an attractive candidate for anticoagulation applications and for promoting endothelial cell adhesion for vascular prostheses.
 
Molecular and Phenotypic Characterization of Aerococcus viridans Associated with Subclinical Bovine Mastitis
2015-04-28 13:51:21 (25 minutes ago) 

by Gang Liu, Yongxia Liu, Tariq Ali, Miro Ferreri, Jian Gao, Wei Chen, Jinhua Yin, Jingliang Su, Séamus Fanning, Bo Han

Aerococcus viridans is a wide spread bacterium in the environment and clinically this organism is associated with different diseases in animals and humans. However, the geno- and phenotypic characterization of A. viridans associated with bovine mastitis has not yet been reported. The objectives of this study were to investigate the genetic and phenotypic diversity of A. viridans isolates using three different molecular methods including 16S rRNA gene sequencing, pulsed-field gel electrophoresis and random amplified polymorphic DNA (RAPD) along with biochemical tests, including antimicrobial susceptibility test. In total, 60 A. viridans strains were cultured from dairy herds presenting with subclinical mastitis. The results of biochemical tests revealed that most of the isolates (75.0%) were accurately identified by API Rapid 20 Strep system and the majority of A. viridans strains (96.7%) were found to be catalase negative, while two (3.3%) isolates were weakly positive. All isolates were resistant to trimethoprim-sulfamethoxazole, followed by streptomycin (96.7%), tetracycline (65.0%) and clindamycin (56.7%) by minimum inhibition concentration-determining broth microdilution technique. As compared to the sequence of 16S rRNA gene, both PFGE and RAPD showed their capacities to discriminate the intra-species diversity of A. viridans. Furthermore, most of the isolates obtained from the same herd or region belonged to the same major RAPD group, which indicated that RAPD is an appropriate assay for tracking the origins of isolates and epidemiological studies of A. viridans. This is a novel approach to use three molecular techniques and to compare their efficiency regarding the genetic diversity of A. viridans. The data suggest that A. viridans associated with subclinical mastitis has a considerable phenotypic and genotypic diversity.
 
Costs and Consequences of Using Interferon-γ Release Assays for the Diagnosis of Active Tuberculosis in India
2015-04-28 13:51:21 (25 minutes ago) 

by Kristen M. Little, Madhukar Pai, David W. Dowdy

Background

There is growing concern that interferon-γ release assays (IGRAs) are being used off-label for the diagnosis of active tuberculosis (TB) disease in many high-burden settings, including India, where the background prevalence of latent TB infection is high. We analyzed the costs and consequences of using IGRAs for the diagnosis of active TB in India from the perspective of the Indian TB control sector.

Methods and Findings

We constructed a decision analytic model to estimate the incremental cost and effectiveness of IGRAs for the diagnosis of active TB in India. We compared a reference scenario of clinical examination and non-microbiological tests against scenarios in which clinical diagnosis was augmented by the addition of either sputum smear microscopy, IGRA, or Xpert MTB/RIF. We examined costs (in 2013 US dollars) and consequences from the perspective of the Indian healthcare sector. Relative to sputum smear microscopy, use of IGRA for active TB resulted in 23,700 (95% uncertainty range, UR: 3,800 – 38,300) additional true-positive diagnoses, but at the expense of 315,700 (95% UR: 118,300 – 388,400) additional false-positive diagnoses and an incremental cost of US$49.3 million (95% UR: $34.9 – $58.0 million) (2.9 billion Indian Rupees). Relative to Xpert MTB/RIF (including the cost of treatment for drug resistant TB), use of IGRA led to 400 additional TB cases treated (95% UR: [-8,000] – 16,200), 370,600 (95% UR: 252,200 – 441,700) more false-positive diagnoses, 70,400 (95% UR: [-7,900] – 247,200) fewer disability-adjusted life years averted, and US$14.6 million (95%UR: [-$7.2] – $28.7 million) (854 million Indian Rupees) in additional costs.

Conclusion

Using IGRAs for diagnosis of active TB in a setting like India results in tremendous overtreatment of people without TB, and substantial incremental cost with little gain in health. These results support the policies by WHO and Standards for TB Care in India, which discourage the use of IGRAs for the diagnosis of active TB in India and similar settings.

 
Antiphospholipid Antibody and Risk of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis
2015-04-28 13:51:21 (25 minutes ago) 

by Wei Zhu, Yan Wu, Ming Xu, Jin-Yu Wang, Yi-Fang Meng, Zheng Gu, Jiong Lu

Background

Retinal vein occlusion (RVO) is a common retinal vascular disease and it is one of the most frequently reported causes of visual damage and blindness in the elderly. The current study investigated the potential association between antiphospholipid antibodies (APLA) and RVO risk by conducting a meta-analysis of case–control studies.

Methods

A systematic literature search of Pubmed and Embase databases was conducted in August 1st, 2014. Odds ratios (ORs) were used to evaluate the associations between APLA and the incidence of RVO. A random-effects model was obtained for the quantitative synthesis.

Results

A total of 11 studies were included in this meta-analysis. A meta-analysis of all studies assessing the risk of RVO revealed that APLA was associated with a statistically increased risk of RVO incidence (OR = 5.18, 95% CI = [3.37, 7.95]). The association between anticardiolipin antibodies (ACA) and the risk of RVO was significant (n =8, OR = 4.59, 95% CI = [2.75, 7.66]). However, the association between lupus anticoagulants (LA) and risk of RVO was non-significant (n = 5, OR = 3.90, 95% CI = [0.99, 15.37]). No significant publication bias was found in the 11 selected studies.

Conclusion

APLA was significantly associated with the risk of RVO. Advanced analyses showed that ACA rather than LA affected the risk of RVO. Additional well-designed and well-conducted epidemiological studies are required to further our understanding of the relationship between APLA and RVO risk.

 
Exercise Physiology and Pulmonary Hemodynamic Abnormality in PH Patients with Exercise Induced Venous-To-Systemic Shunt
2015-04-28 13:51:21 (25 minutes ago) 

by Jian Guo, Xue Shi, Wenlan Yang, Sugang Gong, Qinhua Zhao, Lan Wang, Jing He, Xiaofang Shi, Xingguo Sun, Jinming Liu

Objectives

To identify the pulmonary hypertension (PH) patients who develop an exercise induced venous-to-systemic shunt (EIS) by performing the cardiopulmonary exercise test (CPET), analyse the changes of CPET measurements during exercise and compare the exercise physiology and resting pulmonary hemodynamics between shunt-PH and no-shunt-PH patients.

Methods

Retrospectively, resting pulmonary function test (PFT), right heart catheterization (RHC), and CPET for clinical evaluation of 104 PH patients were studied.

Results

Considering all 104 PH patients by three investigators, 37 were early EIS+, 61 were EIS-, 3 were late EIS+, and 3 others were placed in the discordant group. PeakVO2, AT and OUES were all reduced in the shunt-PH patients compared with the no-shunt-PH subjects, whereas VE/VCO2 slope and the lowest VE/VCO2 increased. Besides, the changes and the response characteristics of the key CPET parameters at the beginning of exercise in the shunt group were notably different from those of the no shunt one. At cardiac catheterization, the shunt patients had significantly increased mean pulmonary artery pressure (mPAP), mean right atrial pressure (mRAP) and pulmonary vascular resistance (PVR), reduced cardiac output (CO) and cardiac index (CI) compared with the no shunt ones (P

 
Drinking Water Turbidity and Emergency Department Visits for Gastrointestinal Illness in New York City, 2002-2009
2015-04-28 13:51:21 (25 minutes ago) 

by Jennifer L. Hsieh, Trang Quyen Nguyen, Thomas Matte, Kazuhiko Ito

Background

Studies have examined whether there is a relationship between drinking water turbidity and gastrointestinal (GI) illness indicators, and results have varied possibly due to differences in methods and study settings.

Objectives

As part of a water security improvement project we conducted a retrospective analysis of the relationship between drinking water turbidity and GI illness in New York City (NYC) based on emergency department chief complaint syndromic data that are available in near-real-time.

Methods

We used a Poisson time-series model to estimate the relationship of turbidity measured at distribution system and source water sites to diarrhea emergency department (ED) visits in NYC during 2002-2009. The analysis assessed age groups and was stratified by season and adjusted for sub-seasonal temporal trends, year-to-year variation, ambient temperature, day-of-week, and holidays.

Results

Seasonal variation unrelated to turbidity dominated (~90% deviance) the variation of daily diarrhea ED visits, with an additional 0.4% deviance explained with turbidity. Small yet significant multi-day lagged associations were found between NYC turbidity and diarrhea ED visits in the spring only, with approximately 5% excess risk per inter-quartile-range of NYC turbidity peaking at a 6 day lag. This association was strongest among those aged 0-4 years and was explained by the variation in source water turbidity.

Conclusions

Integrated analysis of turbidity and syndromic surveillance data, as part of overall drinking water surveillance, may be useful for enhanced situational awareness of possible risk factors that can contribute to GI illness. Elucidating the causes of turbidity-GI illness associations including seasonal and regional variations would be necessary to further inform surveillance needs.

 
Dynamic Metabolic Profiles and Tissue-Specific Source Effects on the Metabolome of Developing Seeds of Brassica napus
2015-04-28 13:51:21 (25 minutes ago) 

by Helin Tan, Qingjun Xie, Xiaoe Xiang, Jianqiao Li, Suning Zheng, Xinying Xu, Haolun Guo, Wenxue Ye

Canola (Brassica napus) is one of several important oil-producing crops, and the physiological processes, enzymes, and genes involved in oil synthesis in canola seeds have been well characterized. However, relatively little is known about the dynamic metabolic changes that occur during oil accumulation in seeds, as well as the mechanistic origins of metabolic changes. To explore the metabolic changes that occur during oil accumulation, we isolated metabolites from both seed and silique wall and identified and characterized them by using gas chromatography coupled with mass spectrometry (GC-MS). The results showed that a total of 443 metabolites were identified from four developmental stages. Dozens of these metabolites were differentially expressed during seed ripening, including 20 known to be involved in seed development. To investigate the contribution of tissue-specific carbon sources to the biosynthesis of these metabolites, we examined the metabolic changes of silique walls and seeds under three treatments: leaf-detachment (Ld), phloem-peeling (Pe), and selective silique darkening (Sd). Our study demonstrated that the oil content was independent of leaf photosynthesis and phloem transport during oil accumulation, but required the metabolic influx from the silique wall. Notably, Sd treatment resulted in seed senescence, which eventually led to a severe reduction of the oil content. Sd treatment also caused a significant accumulation of fatty acids (FA), organic acids and amino acids. Furthermore, an unexpected accumulation of sugar derivatives and organic acid was observed in the Pe- and Sd-treated seeds. Consistent with this, the expression of a subset of genes involved in FA metabolism, sugar and oil storage was significantly altered in Pe and Sd treated seeds. Taken together, our studies suggest the metabolite profiles of canola seeds dynamically varied during the course of oil accumulation, which may provide a new insight into the mechanisms of the oil accumulation at the metabolite level.
 
Auschwitz survivor: Trial of ex-Nazi guard is 'satisfaction'
2015-04-28 13:51:15 (26 minutes ago) 
BERLIN (AP) - An Auschwitz survivor who lost 49 family members in the Holocaust says the fact that a 93-year-old former guard at the death camp is on trial is more important than any punishment.
 
EU looks to cut use of flimsy plastic bags by 80 percent
2015-04-28 13:51:14 (26 minutes ago) 
BRUSSELS (AP) - The European Parliament has approved rules to clamp down on the use of flimsy plastic bags that are hazardous for the environment, removing the last major hurdle to pass the legislation.
 
The Stark Racial Disparity in Perceptions of Police
2015-04-28 13:51:10 (26 minutes ago) 
Less than a third of African-Americans say they're confident that the police in their community treat white and black people equally.
 
Russian Resupply Ship Experiencing Difficulties; International Space Station, Crew are Fine
2015-04-28 13:51:05 (26 minutes ago) 
The six crew members of the International Space Station (ISS) are safe and continuing regular operations with sufficient supplies as Russian flight controllers plan for another attempt to communicate with a cargo resupply spacecraft bound for the station. The next attempt to link with the spacecraft comes at 8:50 p.m. EDT Tuesday.
 
Palm Coast sees solid return on investments
2015-04-28 14:16:20 (28 seconds ago) 
According to the city’s investment consultant, Palm Coast made $419,000 from investment income and interest earnings last year.
 
Nepal quake: Woman saved from rubble 36 hours on
2015-04-28 14:12:45 (4 minutes ago) 
 
ICANN wants total control of DNS while breaking its own bylaws to block .africa probe
2015-04-28 14:12:20 (4 minutes ago) 
Board member ordered to appear at hearing

ICANN broke its own bylaws – and acted in a way "fundamentally inconsistent" with its role as the world's DNS overlord – while restricting efforts to make itself more accountable to netizens.…

 
Elburn cop charged in sexual assault of girl over 10-year period
2015-04-28 14:11:46 (5 minutes ago) 
A longtime Elburn police officer has been charged with sexually assaulting a child over a decade, Kane County prosecutors said Tuesday.
 
“Where Are the Police?”
2015-04-28 14:11:41 (5 minutes ago) 

For a man who has reported from actual war zones and disaster sites, Wolf Blitzer is easily spooked by a bunch of dudes stealing stuff from an urban pharmacy. As CNN aired wide-angle footage Monday of nonchalant looters entering and exiting the chain drugstore near North and Pennsylvania avenues in Baltimore, Blitzer described the scene like it was the fall of Rome: “This is a picture of a CVS pharmacy, and casually people are just going in there—they’re not even running—they’re going in there, stealing whatever the hell they want to steal in there, and then they’re leaving, and they’re … I don’t see any police there. Where are the police?”

 
The Latest on Nepal Quake: UN says 8 million affected
2015-04-28 14:11:33 (5 minutes ago) 
 
Marathon Survivor Adrianne Haslet-Davis Dances Across Finish Line on Prosthetic Leg
2015-04-28 14:11:22 (5 minutes ago) 
A survivor of the 2013 Boston Marathon bombings and former dance instructor who lost the lower half of her left leg danced across the finish line this morning.






 
Shocker endorsement for Maria Quinones-Sanchez
2015-04-28 14:11:18 (6 minutes ago) 
Councilwoman Maria Quinones-Sanchez is set to receive the endorsement of former Councilman (and former Sanchez enemy) Danny Savage.
 
Fired-Up Ray Lewis: 'Baltimore, Get Off the Streets!'
2015-04-28 14:11:13 (6 minutes ago) 
In a portion of a video recorded by Ray Lewis, the former Baltimore Ravens linebacker passionately pleads with people of Baltimore to stop the destruction of the city.
 
Google Now Adds Support for 70 New App Cards
2015-04-28 14:11:05 (6 minutes ago) 

Android: Earlier this year, Google started allowing third-party app developers to place cards in Google Now. Today, the company has announced that they’re greatly expanding this program with support for 70 new apps, including Spotify, Feedly, Runkeeper, OpenTable, and more.

Read more...








 
How Iran's supreme leader became Instagram video supremo
2015-04-28 14:10:55 (6 minutes ago) 

Many Iranian users were puzzled as to how Ayatollah Ali Khamenei was able to post videos exceeding the maximum 15-second time limit. Here’s why

Continue reading...
 
Aid flights to Yemen blocked after Saudi Arabia bombs airport runway
2015-04-28 14:10:55 (6 minutes ago) 

Bombing by aircraft that had ignored warning to turn back intended to prevent Iranian plane landing in Sana’a airport

Continue reading...
 
Lutfur Rahman committed corrupt and illegal practices – this ruling was correct
2015-04-28 14:10:54 (6 minutes ago) 
Continue reading...
 
FBI Warned Cops to Lock Down Their Social Media After Freddie Gray's Death
2015-04-28 14:10:47 (6 minutes ago) 

Two days after Baltimorean Freddie Gray died from a broken spine suffered in police custody, the FBI sent this alert to local law enforcement, warning cops against “cyber attacks” by “hacktivists.”

Read more...








 
P!nk Concert: Not Abuse of Parental Discretion
2015-04-28 14:10:46 (6 minutes ago) 
Moms and dads often disagree in the best of circumstances. In divorce and custody situations, the disagreements can get nasty, and even petty. A divorced New Jersey couple went to court to fight over whether taking their 11-year-old daughter to a P!nk (Pink) concert was abuse of parental discretion. The......
 
Sandwiches Are a Major Contributor to Dietary Sodium Intake
2015-04-28 14:10:42 (6 minutes ago) 
Sandwiches account for one-fifth of total sodium intake, with nearly half of American adults consuming them on any given day, according to new study published in the Journal of the Academy of Nutrition and Dietetics
 
Four big moments from inside the Supreme Court marriage cases
2015-04-28 14:10:38 (6 minutes ago) 

Here are four exchanges from the audio released of the oral arguments on the first question the justices considered: do states have the power to limit marriage? The bottom line consideration here in many ways is, is same-sex marriage a fundamental right and are states that ban same-sex marriages discriminating against gays?

1. A pivotal question for Justice Kennedy

Justice Anthony Kennedy, who is widely expected to be the swing vote on this issue, seemed troubled by the idea of changing the definition of marriage in such short order after marriage being the same institution for "millennia." This indicates a certain hesitation by Kennedy to legalize same-sex marriage nationwide.

"A word that keeps coming back to me in this case is millennia... This definition has been with us for millennia. And it’s very difficult for the court to say, 'Oh, well, we know better.'" Kennedy provided his own counterpoint for that question later in the arguments when he questioned the opponents' attorney, John J. Bursch. Kennedy was particularly worried about affording dignity to same-sex couples and their families: he and other justices felt the fact that same-sex couples raise adopted children undermined opponents' arguments that marriage should be restricted to different-sex couples for child-rearing reasons.
Kennedy: I thought that was the whole purpose of marriage—it bestows dignity on both man and woman in a traditional marriage. ... These parties say they want to have that same ennoblement.

Bursch: If we go back to that world where marriage doesn't exist and the state is trying to figure out, how do we link together these kids with their biological moms and dads when possible, the glue are benefits and burdens, but not necessarily dignity.

Kennedy: Well, I think many states would be surprised that with reference to traditional marriages, they're not enhancing the dignity of both the parties. I'm puzzled by that.

Head below the fold for more on the marriage cases.
 
Motorola Moto E (2nd Gen) Review: Is It Good for Business?
2015-04-28 14:10:33 (6 minutes ago) 
You don't have to spend a lot of money to get a really good business phone.
 
Marathon Survivor Adrianne Haslet-Davis Dances Across Finish Line on Prosthetic Leg
2015-04-28 14:10:32 (6 minutes ago) 
A survivor of the 2013 Boston Marathon bombings and former dance instructor who lost the lower half of her left leg danced across the finish line this morning.






 
Indonesia 'executes drugs prisoners'
2015-04-28 14:10:31 (6 minutes ago) 
Eight convicted drug smugglers have been executed by firing squad in Indonesia, but a Filipina woman has reportedly been spared at the last minute.
 
Ennis-Hill comeback field revealed
2015-04-28 14:10:31 (6 minutes ago) 
Jessica Ennis-Hill and Katarina Johnson-Thompson will face British European champions in next month's Great CityGames.
 
Chicago transit agency blamed for airport train derailment
2015-04-28 14:10:29 (6 minutes ago) 
CHICAGO (AP) -- Chicago's transit agency shares in the blame for an accident last year in which a driver fell asleep and crashed a commuter train into a platform and up an escalator at O'Hare airport, federal investigators concluded Tuesday. And they warned that, without changes, a similar accident could happen elsewhere....
 
The bilingual Bush in Puerto Rico
2015-04-28 14:10:28 (6 minutes ago) 
SAN JUAN, Puerto Rico (AP) -- Jeb Bush confronted one of the Republican Party's touchiest debates head-on Tuesday, telling Puerto Ricans that conservatives should be proud that America is "an immigrant nation" and value the contribution immigrants make to the country....
 
West Bank Universities Call off Elections
2015-04-28 14:10:04 (7 minutes ago) 
West Bank universities call off elections after president's party suffers embarrassing setback
 
Witnesses recount sights, sounds of theater shooting
2015-04-28 14:01:07 (16 minutes ago) 

Prosecutors need to show that James Holmes was sane at time of shooting.

       
 
Lake Michigan Is So Clear That You Can See Shipwrecks In These Photos
2015-04-28 14:00:54 (16 minutes ago) 
A
 
Ray Lewis Tells Baltimore Rioters to ‘Stop the Violence, Go Home’
2015-04-28 14:00:36 (16 minutes ago) 
A
 
Protester inside the Supreme Court
2015-04-28 14:00:21 (16 minutes ago) 
A protester interrupted Supreme Court proceedings on Tuesday during a same-sex marriage case. The man opposed same-sex marriage on religious grounds.
 
Oops. Delray's missed bill payment turns up in audit
2015-04-28 14:00:14 (17 minutes ago) 
It seems like Delray Beach doesn't have automatic bill pay.
 
Marathon Survivor Adrianne Haslet-Davis Dances Across Finish Line on Prosthetic Leg
2015-04-28 14:00:10 (17 minutes ago) 
A survivor of the 2013 Boston Marathon bombings and former dance instructor who lost the lower half of her left leg danced across the finish line this morning.






 
Search Suspended for Missing Fisherman; Man Rescued in 2014
2015-04-28 14:00:01 (17 minutes ago) 
Coast Guard suspends search for missing Hawaii fisherman who survived previous ordeal at sea
 
Iran fires on, seizes cargo ship in Gulf, prompting U.S. Navy patrol
2015-04-28 13:56:20 (20 minutes ago) 
An Iranian naval patrol fired warning shots across the bow of a Marshall Islands-flagged container ship Tuesday, forcing the vessel into an Iranian port where its crewmembers were detained, Middle East news agencies and the Pentagon reported.
 
Mark David Chapman Fast Facts
2015-04-28 13:52:49 (24 minutes ago) 
 
The LG G4 Has A Leather Jacket and a Great Camera
2015-04-28 13:51:50 (25 minutes ago) 

LG's new flagship phone gets upgraded inside and out, with a full-grain leather backing and one of the best cameras in the smartphone realm.

The post The LG G4 Has A Leather Jacket and a Great Camera appeared first on WIRED.








 
Barcelona v Getafe: La Liga – live!
2015-04-28 13:51:41 (25 minutes ago) 
La Liga updates from the 7pm BST kick-off at Camp NouLive scoreboard! Follow all the day’s goals and games as they happenEmail jacob.steinberg@theguardian.com or tweet @JacobSteinbergFollow Bayern Munich v Borussia Dortmund here

6.50pm BST

“Are you really in Spain?” says Tony Waters. “Or be thee covering this while watching t.v. in London?”

I’m sitting next to Luis Enrique right now.

6.38pm BST

Jordi Alba is suspended after his red card in Saturday’s tempestuous 2-0 win at Espanyol and Gerard Pique is missing, while Andres Iniesta, Ivan Rakitic and Javier Mascherano are on the bench. Which is understandable given that Bayern Munich visit Camp Nou next Tuesday.

6.36pm BST

At first glance, this looks like a foregone conclusion. But consider this: a 2-2 draw with Getafe at Camp Nou during the run-in last season ultimately put a huge dent in Barcelona’s chances of winning the title, Angel Lafita scoring a last-minute equaliser for the visitors. And it was 0-0 when these two sides met in Madrid in December. Could it be that Getafe are Barcelona’s bogey side?

6.29pm BST

Barcelona: Bravo; Alves, Bartra, Mathieu, Adriano; Busquets, Rafinha, Xavi; Messi, Suarez, Neymar. Subs: Ter Stegen, Montoya, Mascherano, Rakitic, Sergi Roberto, Pedro, Iniesta.

Getafe: Guaita, Alexis, Lago, Velázquez, Lacen, Arroyo, Pedro León, Babá, Juan Rodríguez, Freddy, Emi.

6.00pm BST

Hello. You may be surprised to learn that the La Liga title race is being fought over by Barcelona and Real Madrid. Who could have predicted that, eh? Barcelona lead by two points and with Real Madrid hosting Almeria tomorrow, there is no room for any slip-ups against Getafe at Camp Nou this evening. I imagine they’ll be fine. You tend to be fine when you have Lionel Messi, Neymar and Luis Suarez up front.

Kick-off: 7pm in London, 8pm in Catalunya.

Continue reading...
 
Report: Dolphins' Dion Jordan suspended for entire 2015 season
2015-04-28 13:51:37 (25 minutes ago) 
Miami Dolphins defensive end Dion Jordan has been suspended for the entire 2015 season because of a violation of the league's substance abuse policy, according to ESPN.
 
Robert Redford has rare reunion with children and grandchildren as he receives Chaplin Award
2015-04-28 13:51:35 (25 minutes ago) 
 
Charges dropped against one man accused in Greyhound bus bomb threat in Lake County
2015-04-28 13:51:29 (25 minutes ago) 
 
Intravaginal Lactic Acid Bacteria Modulated Local and Systemic Immune Responses and Lowered the Incidence of Uterine Infections in Periparturient Dairy Cows
2015-04-28 13:51:21 (25 minutes ago) 

by Qilan Deng, John F. Odhiambo, Umar Farooq, Tran Lam, Suzanna M. Dunn, Burim N. Ametaj

The objective of this investigation was to evaluate whether intravaginal infusion of a lactic acid bacteria (LAB) cocktail around parturition could influence the immune response, incidence rate of uterine infections, and the overall health status of periparturient dairy cows. One hundred pregnant Holstein dairy cows were assigned to 1 of the 3 experimental groups as follows: 1) one dose of LAB on wk -2 and -1, and one dose of carrier (sterile skim milk) on wk +1 relative to the expected day of parturition (TRT1); 2) one dose of LAB on wk -2, -1, and +1 (TRT2), and 3) one dose of carrier on wk -2, -1, and +1 (CTR). The LAB were a lyophilized culture mixture composed of Lactobacillus sakei FUA3089, Pediococcus acidilactici FUA3138, and Pediococcus acidilactici FUA3140 with a cell count of 108-109 cfu/dose. Blood samples and vaginal mucus were collected once a week from wk -2 to +3 and analyzed for content of serum total immunoglobulin G (IgG), lipopolysaccharide-binding protein (LBP), serum amyloid A (SAA), haptoglobin (Hp), tumor necrosis factor (TNF), interleukin (IL)-1, IL-6, and vaginal mucus secretory IgA (sIgA). Clinical observations including rectal temperature, vaginal discharges, retained placenta, displaced abomasum, and laminitis were monitored from wk -2 to +8 relative to calving. Results showed that intravaginal LAB lowered the incidence of metritis and total uterine infections. Intravaginal LAB also were associated with lower concentrations of systemic LBP, an overall tendency for lower SAA, and greater vaginal mucus sIgA. No differences were observed for serum concentrations of Hp, TNF, IL-1, IL-6 and total IgG among the treatment groups. Administration with LAB had no effect on the incidence rates of other transition cow diseases. Overall intravaginal LAB lowered uterine infections and improved local and systemic immune responses in the treated transition dairy cows.
 
Multilocus Sequence Typing of Pathogenic Candida albicans Isolates Collected from a Teaching Hospital in Shanghai, China: A Molecular Epidemiology Study
2015-04-28 13:51:21 (25 minutes ago) 

by Kefei Wu, Tao Luo, Li Li, Qiangqiang Zhang, Junhao Zhu, Qian Gao, Min Chen, Min Zhu

Molecular typing of Candida albicans is important for studying the population structure and epidemiology of this opportunistic yeast, such as population dynamics, nosocomial infections, multiple infections and microevolution. The genetic diversity of C. albicans has been rarely studied in China. In the present study, multilocus sequence typing (MLST) was used to characterize the genetic diversity and population structure of 62 C. albicans isolates collected from 40 patients from Huashan Hospital in Shanghai, China. A total of 50 diploid sequence types (DSTs) were identified in the 62 C. albicans isolates, with 41 newly identified DSTs. Based on cluster analysis, the 62 isolates were classified into nine existing clades and two new clades (namely clades New 1 and New 2). The majority of the isolates were clustered into three clades, clade 6 (37.5%), clade 1 (15.0%) and clade 17 (15.0%). Isolates of clade New 2 were specifically identified in East Asia. We identified three cases of potential nosocomial transmission based on association analysis between patients’ clinical data and the genotypes of corresponding isolates. Finally, by analyzing the genotypes of serial isolates we further demonstrated that the microevolution of C. albicans was due to loss of heterozygosity. Our study represents the first molecular typing of C. albicans in eastern China, and we confirmed that MLST is a useful tool for studying the epidemiology and evolution of C. albicans.
 
Applying Personal Genetic Data to Injury Risk Assessment in Athletes
2015-04-28 13:51:21 (25 minutes ago) 

by Gabrielle T. Goodlin, Andrew K. Roos, Thomas R. Roos, Claire Hawkins, Sydney Beache, Stephen Baur, Stuart K. Kim

Recent studies have identified genetic markers associated with risk for certain sports-related injuries and performance-related conditions, with the hope that these markers could be used by individual athletes to personalize their training and diet regimens. We found that we could greatly expand the knowledge base of sports genetic information by using published data originally found in health and disease studies. For example, the results from large genome-wide association studies for low bone mineral density in elderly women can be re-purposed for low bone mineral density in young endurance athletes. In total, we found 124 single-nucleotide polymorphisms associated with: anterior cruciate ligament tear, Achilles tendon injury, low bone mineral density and stress fracture, osteoarthritis, vitamin/mineral deficiencies, and sickle cell trait. Of these single nucleotide polymorphisms, 91% have not previously been used in sports genetics. We conducted a pilot program on fourteen triathletes using this expanded knowledge base of genetic variants associated with sports injury. These athletes were genotyped and educated about how their individual genetic make-up affected their personal risk profile during an hour-long personal consultation. Overall, participants were favorable of the program, found it informative, and most acted upon their genetic results. This pilot program shows that recent genetic research provides valuable information to help reduce sports injuries and to optimize nutrition. There are many genetic studies for health and disease that can be mined to provide useful information to athletes about their individual risk for relevant injuries.
 
Identifying Human Genome-Wide CNV, LOH and UPD by Targeted Sequencing of Selected Regions
2015-04-28 13:51:21 (25 minutes ago) 

by Wei Li, Yingying Xia, Chongzhi Wang, Y. Tom Tang, Wenying Guo, Jinliang Li, Xia Zhao, Yepeng Sun, Juan Hu, Hefu Zhen, Xiandong Zhang, Chao Chen, Yujian Shi, Lin Li, Hongzhi Cao, Hongli Du, Jian Li

Copy-number variations (CNV), loss of heterozygosity (LOH), and uniparental disomy (UPD) are large genomic aberrations leading to many common inherited diseases, cancers, and other complex diseases. An integrated tool to identify these aberrations is essential in understanding diseases and in designing clinical interventions. Previous discovery methods based on whole-genome sequencing (WGS) require very high depth of coverage on the whole genome scale, and are cost-wise inefficient. Another approach, whole exome genome sequencing (WEGS), is limited to discovering variations within exons. Thus, we are lacking efficient methods to detect genomic aberrations on the whole genome scale using next-generation sequencing technology. Here we present a method to identify genome-wide CNV, LOH and UPD for the human genome via selectively sequencing a small portion of genome termed Selected Target Regions (SeTRs). In our experiments, the SeTRs are covered by 99.73%~99.95% with sufficient depth. Our developed bioinformatics pipeline calls genome-wide CNVs with high confidence, revealing 8 credible events of LOH and 3 UPD events larger than 5M from 15 individual samples. We demonstrate that genome-wide CNV, LOH and UPD can be detected using a cost-effective SeTRs sequencing approach, and that LOH and UPD can be identified using just a sample grouping technique, without using a matched sample or familial information.
 
Hybrid De Novo Genome Assembly Using MiSeq and SOLiD Short Read Data
2015-04-28 13:51:21 (25 minutes ago) 

by Tsutomu Ikegami, Toyohiro Inatsugi, Isao Kojima, Myco Umemura, Hiroko Hagiwara, Masayuki Machida, Kiyoshi Asai

A hybrid de novo assembly pipeline was constructed to utilize both MiSeq and SOLiD short read data in combination in the assembly. The short read data were converted to a standard format of the pipeline, and were supplied to the pipeline components such as ABySS and SOAPdenovo. The assembly pipeline proceeded through several stages, and either MiSeq paired-end data, SOLiD mate-paired data, or both of them could be specified as input data at each stage separately. The pipeline was examined on the filamentous fungus Aspergillus oryzae RIB40, by aligning the assembly results against the reference sequences. Using both the MiSeq and the SOLiD data in the hybrid assembly, the alignment length was improved by a factor of 3 to 8, compared with the assemblies using either one of the data types. The number of the reproduced gene cluster regions encoding secondary metabolite biosyntheses (SMB) was also improved by the hybrid assemblies. These results imply that the MiSeq data with long read length are essential to construct accurate nucleotide sequences, while the SOLiD mate-paired reads with long insertion length enhance long-range arrangements of the sequences. The pipeline was also tested on the actinomycete Streptomyces avermitilis MA-4680, whose gene is known to have high-GC content. Although the quality of the SOLiD reads was too low to perform any meaningful assemblies by themselves, the alignment length to the reference was improved by a factor of 2, compared with the assembly using only the MiSeq data.
 
Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans
2015-04-28 13:51:21 (25 minutes ago) 

by Joost Monen, Neil Hattersley, Andrew Muroyama, Deanna Stevens, Karen Oegema, Arshad Desai

Centromeres are defined epigenetically in the majority of eukaryotes by the presence of chromatin containing the centromeric histone H3 variant CENP-A. Most species have a single gene encoding a centromeric histone variant whereas C. elegans has two: HCP-3 (also known as CeCENP-A) and CPAR-1. Prior RNAi replacement experiments showed that HCP-3 is the functionally dominant isoform, consistent with CPAR-1 not being detectable in embryos. GFP::CPAR-1 is loaded onto meiotic chromosomes in diakinesis and is enriched on bivalents until meiosis I. Here we show that GFP::CPAR-1 signal loss from chromosomes precisely coincides with homolog segregation during anaphase I. This loss of GFP::CPAR-1 signal reflects proteolytic cleavage between GFP and the histone fold of CPAR-1, as CPAR-1::GFP, in which GFP is fused to the C-terminus of CPAR-1, does not exhibit any loss of GFP signal. A focused candidate screen implicated separase, the protease that initiates anaphase by cleaving the kleisin subunit of cohesin, in this cleavage reaction. Examination of the N-terminal tail sequence of CPAR-1 revealed a putative separase cleavage site and mutation of the signature residues in this site eliminated the cleavage reaction, as visualized by retention of GFP::CPAR-1 signal on separating homologous chromosomes at the metaphase-anaphase transition of meiosis I. Neither cleaved nor uncleavable CPAR-1 were centromere-localized in mitosis and instead localized throughout chromatin, indicating that centromere activity has not been retained in CPAR-1. Although the functions of CPAR-1 and of its separase-dependent cleavage remain to be elucidated, this effort reveals a new substrate of separase and provides an in vivo biosensor to monitor separase activity at the onset of meiosis I anaphase.
 
Facilitation of Visual Perception in Head Direction: Visual Attention Modulation Based on Head Direction
2015-04-28 13:51:21 (25 minutes ago) 

by Ryoichi Nakashima, Satoshi Shioiri

People usually see things using frontal viewing, and avoid lateral viewing (or eccentric gaze) where the directions of the head and eyes are largely different. Lateral viewing interferes with attentive visual search performance, probably because the head is directed away from the target and/or because the head and eyes are misaligned. In this study, we examined which of these factors is the primary one for interference by conducting a visual identification experiment where a target was presented in the peripheral visual field. The critical manipulation was the participants’ head direction and fixation position: the head was directed to the fixation location, the target position, or the opposite side of the fixation. The performance was highest when the head was directed to the target position even when there was misalignment of the head and eye, suggesting that visual perception can be influenced by both head direction and fixation position.
 
Cervical Lymph Nodes as a Selective Niche for Brucella during Oral Infections
2015-04-28 13:51:21 (25 minutes ago) 

by Kristine von Bargen, Aurélie Gagnaire, Vilma Arce-Gorvel, Béatrice de Bovis, Fannie Baudimont, Lionel Chasson, Mile Bosilkovski, Alexia Papadopoulos, Anna Martirosyan, Sandrine Henri, Jean-Louis Mège, Bernard Malissen, Jean-Pierre Gorvel

Cervical lymph nodes (CLN) are the first lymph nodes encountered by material taking the oral route. To study their role in orally acquired infections, we analyzed 307 patients of up to 14 years treated in the university clinic of Skopje, Macedonia, for brucellosis, a zoonotic bacterial disease frequently acquired by ingestion of contaminated dairy products. From these children, 36% had lymphadenopathy. Among orally infected children, lymphadenopathy with CLN being the only lymph nodes affected was significantly more frequent as compared to those infected by contact with animals (83% vs. 63%), suggesting a possible involvement of CLN during orally acquired human brucellosis. Using a murine model where bacteria are delivered into the oral cavity, we show that Brucella quickly and selectively colonize the CLN where they proliferate and persist over long periods of time for up to 50 days post-infection. A similar efficient though less specific drainage to CLN was found for Brucella, Salmonella typhimurium and fluorescent microspheres delivered by gavage, a pathway likely representing a mixed infection mode of intragastric and oral infection, suggesting a central pathway of drained material. Microspheres as well as bacteria drained to CLN predominately reside in cells expressing CD68 and no or low levels of CD11c. Even though no systemic response could be detected, Brucella induced a locally restricted inflammatory reaction with increased expression levels of interferon γ, interleukin (IL)-6, IL-12, granzyme B and a delayed induction of Nos2. Inflammation led to pronounced lymphadenopathy, infiltration of macrophages/monocytes expressing high levels of major histocompatibility complex II and to formation of epitheloid granulomas. Together, these results highlight the role of CLN in oral infections as both, an initial and efficient trap for bacterial invaders and as possible reservoir for chronic pathogens. They likewise cast a new light on the significance of oral routes for means of vaccination.
 
EU looks to cut use of flimsy plastic bags by 80 percent
2015-04-28 13:51:15 (26 minutes ago) 
BRUSSELS (AP) - The European Parliament has approved rules to clamp down on the use of flimsy plastic bags that are hazardous for the environment, removing the last major hurdle to pass the legislation.
 
N.J. sending state troopers to Baltimore
2015-04-28 13:51:14 (26 minutes ago) 
New Jersey is deploying 150 state police and other personnel to Baltimore, Gov. Christie said Tuesday, a day after riots broke out in the city.
 
Baltimore Riots: Larry Hogan says more law enforcement being deployed to restore order
2015-04-28 13:51:06 (26 minutes ago) 

Though the riots and looting that rocked Baltimore Monday night had subsided by Tuesday morning, Maryland Gov. Larry Hogan said additional law enforcement are being deployed to ensure chaos will not take hold of the city again when the sun goes down.

"To my knowledge, there have been no incidents ...

 
'They're Stealing': Obama Speaks Out on Baltimore Rioters
2015-04-28 13:51:04 (26 minutes ago) 
President Obama sounds off on a recent wave of incidents involving force by police in communities across America.






 
Palm Coast sees solid return on investments
2015-04-28 14:16:16 (32 seconds ago) 
According to the city’s investment consultant, Palm Coast made $419,000 from investment income and interest earnings last year.
 
UN refugee agency assists hundreds of Libyans rescued at sea as Europe responds to migration crisis
2015-04-28 14:12:23 (4 minutes ago) 
The heads of United Nations agencies with a stake in the current crisis in the Mediterranean Sea have pledged to working closely with the European Union (EU) following its decision “to mobilize all efforts at its disposal to prevent further loss of life at sea and to tackle the root causes of the human emergency.”
 
Tories accused of playing politics with Trident after defence debate
2015-04-28 14:12:19 (4 minutes ago) 

Defence secretary Michael Fallon refuses six times to confirm whether his party would vote to renew Britain’s nuclear deterrent under a Labour government

The Conservatives have been accused of playing politics with Britain’s nuclear deterrent after the defence secretary refused six times to confirm whether the Tories would vote to renew Trident under a Labour government.

Michael Fallon ran into trouble during a BBC2 debate when his Labour shadow, Vernon Coaker, challenged him about his claim that Ed Miliband would “barter away” Trident as part of a deal with the SNP to get into No 10.

Continue reading...
 
College of DuPage trustees battle for control
2015-04-28 14:11:46 (5 minutes ago) 
A newly elected majority of College of DuPage trustees wants to vote Thursday to remove embattled president Robert Breuder -- but the old board appears to be standing in its way. 






 
Researchers Mount Cyberattacks Against Surgery Robot
2015-04-28 14:11:40 (5 minutes ago) 
An anonymous reader writes: A group of researchers from University of Washington have tested the security of a teleoperated robotic surgery system created by their colleagues, and have found it severely lacking. "Teleoperated surgical robots will be expected to use a combination of existing publicly available networks and temporary ad-hoc wireless and satellite networks to send video, audio and other sensory information between surgeons and remote robots. It is envisioned these systems will be used to provide immediate medical relief in under-developed rural terrains, areas of natural and human-caused disasters, and in battlefield scenarios," the researchers noted, and asked: "But what if these robotic systems are attacked and compromised?"

Read more of this story at Slashdot.

 
With Josh Hamilton gone, Angels need help out of left field
2015-04-28 14:11:32 (5 minutes ago) 
 
Why New England Is Such a Hotbed for Skin Cancer
2015-04-28 14:11:22 (5 minutes ago) 
Why is a Boston city councilor pushing to give out sunscreen for free? That’s because Boston — and New England writ large — has some of the highest rates of skin cancer in the country.






 
Fundraiser set for slain cop's family
2015-04-28 14:11:18 (6 minutes ago) 
A Wissinoming restaurant will hold a fundraiser tomorrow for the family of slain Philadelphia Officer Robert Wilson III.
 
Ending Iran sanctions could hurt Revolutionary Guard
2015-04-28 14:11:11 (6 minutes ago) 
Iranian president warns that a nuclear deal with the West would hurt the powerful middleman and smugglers currently flourishing on black market
 
'Bali Nine' pair among eight executed for drug offences in Indonesia
2015-04-28 14:10:55 (6 minutes ago) 

Australians Andrew Chan and Myuran Sukumuran among eight executed as high-level campaign for clemency failed to sway Indonesian president

Continue reading...
 
Tories accused of playing politics with Trident after defence debate
2015-04-28 14:10:55 (6 minutes ago) 

Defence secretary Michael Fallon refuses six times to confirm whether his party would vote to renew Britain’s nuclear deterrent under a Labour government

Continue reading...
 
Parties need a dose of realism over NHS funding promises
2015-04-28 14:10:54 (6 minutes ago) 
Continue reading...
 
Austerity, low productivity and shrinking growth – it’s the stupid economy
2015-04-28 14:10:54 (6 minutes ago) 
Continue reading...
 
April Is Distracted Driving Month
2015-04-28 14:10:46 (6 minutes ago) 
April Fools' Day is behind us, and Tax Day is starting to fade from memory. But before April -- also known as Distracted Driving Month -- comes to a close, you should remind yourself of the distracted driving laws that exist in your and many other states. To get......
 
Darius McCrary Violates Visitation Order, Pays $15K Bond
2015-04-28 14:10:46 (6 minutes ago) 
Don't mess with a visitation order and an angry mama. Darius McCrary, of Family Matters fame, recently took his son on a father-son Spring Break Trip and stayed too long. The son's mother, Elizabeth Alanoly, filed an emergency motion with the court after McCrary didn't return his son on......
 
EFF's Updated SSL Configuration
2015-04-28 14:10:38 (6 minutes ago) 

EFF recently updated our SSL certificate and configuration. This gave us an A+ rating on SSL Labs, a great jumping off point for reviewing a site's secure connection. What follows is a quick, technical guide to how we achieved this.

Generating a Certificate

First we generate an 4096-bit RSA private key with a strong passphrase. It's useful to have a "locked" version of the key for secure archival. The passphrase is stored separately in a KeePassX database.

openssl genrsa -aes256 -out example.com.aes 4096

Next we update a .cnf file to populate the fields we want filled into the final certificate. This is especially useful when the certificate uses the Subject Alternative Name field to specify additional domain names. Here's the format:

[req]
distinguished_name = req_distinguished_name
req_extensions = v3_req

[req_distinguished_name]
countryName = Country Name (2 letter code)
countryName_default = XX
stateOrProvinceName = State or Province Name (full name)
stateOrProvinceName_default = Somewhere
localityName = Locality Name (eg, city)
localityName_default = Sometown
organizationalUnitName  = Organizational Unit Name (eg, section)
organizationalUnitName_default  = SomeCo
commonName = Common Name (ie hostname or username)
commonName_default = example.example.com
commonName_max  = 64

[ v3_req ]
basicConstraints = CA:FALSE
keyUsage = digitalSignature, keyEncipherment
subjectAltName = @alt_names

[alt_names]
DNS.1 = example.com
DNS.2 = www.example.com
DNS.3 = poorlykeptsecret.example.com

Next we generate a Certificate Signing Request (CSR), which a Certificate Authority will use as input for the final certificate:

openssl req -new -out example.com.csr -key example.com.aes -config example.com.cnf

We prove to our chosen Certificate Authority (CA) that we control all the DNS names in the certificate, then we send example.com.csr to the CA so it can sign a certificate using the provided public key and name information. Unfortunately, the process for doing these two steps varies greatly for each CA, so it's hard to provide universal advice. We are working with Mozilla and several other organizations on the ACME protocol to simplify the proof and issuance process, along with a new Certificate Authority, Let's Encrypt, that will issue certificates free of charge using the ACME protocol, making the process easier.

When choosing a Certificate Authority, you should double-check that your CA will issue you a certificate using the SHA256 hashing algorithm. SHA256 is rapidly replacing the deprecated SHA1 hashing algorithm, and is being phased out of support by browsers.

Most CAs provide your final certificate and their intermediate chain certificate  in two separate files, but nginx prefers them concatenated into a single .pem file (order is important):

cat example.com.crt My_CA_Intermedate.crt >> example.com.pem

In order for nginx to be able to start without entering a passphrase, we need to unlock we created earlier:

sudo openssl rsa -in example.com.aes -out /etc/ssl/private/example.com.key

Nginx Configuration

Most of the heavy lifting is done in the file /etc/nginx/ssl.conf:

ssl_prefer_server_ciphers on;

ssl_ciphers ECDH+AESGCM:ECDH+AES256:ECDH+AES128:ECDH+3DES:RSA+AES:RSA+3DES:!ADH:!AECDH:!MD5:!DSS;

ssl_protocols TLSv1 TLSv1.1 TLSv1.2;
add_header Strict-Transport-Security "max-age=31536000; includeSubdomains";

ssl_prefer_server_ciphers is important to make sure the somewhat weaker ciphers lower on the list are only used if browsers don't support those listed first.

ssl_ciphers enables only ciphers without major known vulnerabilities, and lists ciphers with Perfect Forward Secrecy first.

ssl_protocols does not include SSLv3. Unfortunately, browser support for TLSv1.2 is not widespread enough to disable TLSv1 and TLSv1.1.

The Strict-Transport-Security header tells browsers to make only secure connections to this domain for the number of seconds specified by max-age. This is important to help prevent a variety of attacks that rely on downgrades or domain spoofing. The optional includesSubdomains flag will affect every subdomain as soon as a browser has visited this site once, so it should be enabled with care.

In the server block for the host (eg in sites-enabled), use an include statement for ssl.conf. We all redirect all plain HTTP visitors on port 80 to HTTPS, where they will receive the HSTS header and know to alway try a secure connection in the future.

server {
  listen 80;
  server_name example.com;
  rewrite ^(.*)$ https://example.com$1 permanent;
}

server {
  ssl_certificate /etc/ssl/certs/example.com.pem;
  ssl_certificate_key /etc/ssl/private/example.com.key;
  listen 443 ssl;
  server_name example.com;
  include /etc/nginx/ssl.conf;
  ...
  }
}

Providing SSL is an important step in protecting your users. Configuring SSL securely isn't easy, and keeping your server secure requires frequent updates, but we hope this guide will help more administrators get there.

Related Issues: Security
Share this:   ||  Join EFF
 
Powerful images, reaction from the Baltimore riots
2015-04-28 14:10:35 (6 minutes ago) 

Social media has been flooded with images from the riots that erupted in Baltimore Monday just hours after the funeral for Freddie Gray. Gray died from a spinal injury he sustained while in police custody.

        
 
Marathon Survivor Adrianne Haslet-Davis Dances Across Finish Line on Prosthetic Leg
2015-04-28 14:10:33 (6 minutes ago) 
A survivor of the 2013 Boston Marathon bombings and former dance instructor who lost the lower half of her left leg danced across the finish line this morning.






 
Tesla to open the electric car doors to hackers at Defcon 2015
2015-04-28 14:10:31 (6 minutes ago) 

Photo: teslamotors.com

At the Defcon convention in Las Vegas this summer, one of Elon Musk’s Tesla electric cars will be made available to hacker attendees, so they can tinker with any piece of the vehicle they like.

Read the rest
 
VIDEO: Restaurant scoured for quake survivors
2015-04-28 14:10:31 (6 minutes ago) 
Rescuers in Nepal are still hopeful that they will find some survivors amongst the wreckage, although a lot of bodies are also being found.
 
Indonesia 'executes drugs prisoners'
2015-04-28 14:10:31 (6 minutes ago) 
Eight convicted drug smugglers have been executed by firing squad in Indonesia, but a Filipina woman has reportedly been spared at the last minute.
 
The bilingual Bush in Puerto Rico
2015-04-28 14:10:29 (6 minutes ago) 
SAN JUAN, Puerto Rico (AP) -- Jeb Bush confronted one of the Republican Party's touchiest debates head-on Tuesday, telling Puerto Ricans that conservatives should be proud that America is "an immigrant nation" and value the contribution immigrants make to the country....
 
Supreme Court Right-Wingers Openly Hostile To Full Same-Sex Marriage Rights
2015-04-28 14:10:28 (6 minutes ago) 
The equality struggle will move slowly if it moves at all.

The U.S. Supreme Court’s conservatives don’t like same-sex marriage, and that could mean that the civil rights struggle for LBGT equality will continue for years.

Starting with Chief Justice John Roberts, the court’s conservatives gave no indication during three hours of oral arguments Tuesday morning that they believe LGBT Americans deserve the full panapoly of constitutional rights, liberties and protections.

Early in hearing oral arguments in Obergefell v. Hodges, which is consolidated with three other cases on the questions of whether same-sex marriage is a constitutional right, and whether states have to recognize marriages from other states, Roberts said that he had looked up definitions of marriage and it did not include same-sex couples. “You are seeking to change the institution,” he said.

That was followed by Justice Anthony Kennedy, who asked two questions that seemed to telegraph the Court would take a piecemeal approach when ruling. Kennedy said the institution of marriage had been around for “millenia,” referring to traditional marriage. But he also noted the reality that same-sex couples are adopting and raising children, and thus deserved some legal protection.

Kennedy’s comments are being watched because he was the lead author in the court’s last major LGBT ruling, U.S. v. Windsor, which forced the federal agencies to recognize same-sex marriage licenses issued by states. Other right-wing justices, namely Antonin Scalia, followed Kennedy’s cues, asking if any other country recognized same-sex marriage before the Netherlands in 2001.

After a protester interrupted the hearing shouting that “homosexuality is an abomination,” Scalia commented that was “kind of refreshing,” and said that creating new same-sex marriage rights would be “unpalatable” to religious people. Justice Samuel Alito asked whether states that have banned same-sex marriage “seek to demean gay people?”    

The court’s liberal minority, meanwhile, pushed back by asking why same-sex couples were being denied equal treatment under the law. Justice Stephen Breyer said that marriage is open to multitudes but not same-sex couples, “And so we ask why?” He asked lawyers to comment on the appropriateness of the Court overruling voter-approved anti-LGBT state constitutional amendments.

Justice Ruth Bader-Ginsburg was flustered that the Court's conservatives seemed intent on defending the institution of traditional marriage instead of looking at the indignities and harms that discriminatory anti-LGBT laws have on same-sex households.

“You are not taking away anything from heterosexual couples” if states allow same-sex marriage, she said. Similarly, Justice Sonia Sotomayor asked how denying rights to same-sex couples fortifies traditional marriages?

The answers from lawyers opposing same-sex marriage have been heard for years in the right-wing culture wars. John Bursch said that if marriage and child-bearing are not related, then more children would be born outside of marriage and that harms society.

The Big Picture

The reason that this case is so important is because it invites the Court to create a new legal landscape surrounding the constitutional rights to same-sex marriage—and protection from state laws that discriminate by treating same-sex couples unequally. Whatever the Court decides in its ruling expected this June will likely hold for many years—at least until the Court’s conservatives are replaced.

Legally, marriage is a state-granted contract that triggers many other rights and benefits under state and federal laws. In that sense, marriage rights are a proxy for all kinds of other societal issues—from adoption and parenting rights, to property ownership rights, to medical power of attorney and inheritance rights, to one’s status for tax filing purposes, and more. While conservatives rail about the harm to family values as they see them, LGBT activists—much like African-Americans in the Civil Rights Movement—know that they have been excluded from many of the legal protections and benefits conferred by the courts, state and federal government.

Literally hundreds of state and federal laws confer benefits to married couples—including seemingly small things such as parents’ names on birth certificates to last names on drivers’ licenses. That backdrop invites a matrix of half-measures that the Supreme Court could confer, even if it validates same-sex marriage. The two big questions in this case are whether states must allow same-sex couples to marry, and whether states must recognize marriages from other states. LGBT activists seek strong, unambiguous, affirmative rulings.

However, the Court could affirm same-sex marriage and still give red states plenty of leeway to preserve discriminatory practices. If, for example, the Court’s majority does not explicitly affirm equal protection, then it would be much harder to challenge state laws that discriminate against LGBT individuals—usually by intentional omission, such as not listing LGBT individuals among the classes of people being granted legal protection from discrimination.

Moreover, the Court’s conservatives could also undermine a holding that same-sex couples were entitled to equal protection by watering down the legal standard needed to prove discrimination in court. That prospect would make it much harder for LGBT advocates, who could win the right to marry, to go further and overturn state laws that prevent full spousal rights.

Similarly, the Court’s conservatives could take a “state’s rights” approach and leave it up to states to work out the details of the implications of recognizing same-sex marriage, which, in many red states would become an invitation to do very little.

What was obvious from the oral arguments on Tuesday was that the Court's right-wing majority was in no mood to embrace full constitutional and legal protections for same-sex couples. That more than suggests that even if the Court approves same-sex marriage rights, it would take years to legally dismantle the many facets of discrimination facing same-sex households.  

 

 Related Stories15 Personal Insults That Brought Same-Sex Marriage To The Supreme CourtJustice Department to Go After Ferguson for Racist Policing, Not for Killing Michael BrownOregon's Incoming Governor, Kate Brown, Is Nation's First Bisexual State Executive
 
Saudi Arabia foils U.S. Embassy attack, arrests 93 suspects
2015-04-28 14:01:08 (16 minutes ago) 

The suspects had ties to the Islamic State and were planning multi-pronged attacks, Saudi Arabia says.

        
 
Restaurant sorry about Bruce Jenner 'hotdog of the day'
2015-04-28 14:01:07 (16 minutes ago) 

The owner of the gourmet hot-dog restaurant Senate in Over-the-Rhine apologized Monday for the name of a menu item referring to Olympic gold...

       
 
Meet the Amateur Photographer Covering Baltimore’s Protests
2015-04-28 14:00:36 (16 minutes ago) 
A
 
Somali Refugees Fear Being Thrown Out of Kenya
2015-04-28 14:00:36 (16 minutes ago) 
A
 
Baltimore's riots and 'The Purge'
2015-04-28 14:00:19 (16 minutes ago) 
 
Obama, Abe declare progress, but no breakthrough, on trade
2015-04-28 14:00:13 (17 minutes ago) 
 
Marathon Survivor Adrianne Haslet-Davis Dances Across Finish Line on Prosthetic Leg
2015-04-28 14:00:07 (17 minutes ago) 
A survivor of the 2013 Boston Marathon bombings and former dance instructor who lost the lower half of her left leg danced across the finish line this morning.






 
National Football League giving up tax-exempt status
2015-04-28 13:58:45 (18 minutes ago) 
In a letter to team owners, NFL Commissioner Roger Goodell says the league office and its management council will file tax returns as taxable entities for the 2015 fiscal year.
 
Robert Downey Jr calls British journalist 'bottom-feeding muckraker'
2015-04-28 13:55:04 (22 minutes ago) 

The actor who walked out of an interview with Krishnan Guru-Murthy said he was being ‘scrutinised like a kiddie-fiddler who’s running for mayor’

Robert Downey Jr has spoken for the first time about walking out of an interview with British journalist Krishnan Guru-Murthy, calling the Channel 4 News reporter a “bottom-feeding muckraker”.

Speaking to US radio host Howard Stern, Downey Jr professed himself unrepentant about the incident, saying “I just wish I’d left sooner.”

Continue reading...
 
Russia Fast Facts
2015-04-28 13:52:49 (24 minutes ago) 
 
Man cooked in oven with 12,000 pounds of tuna
2015-04-28 13:51:47 (25 minutes ago) 

Bumble Bee Foods and two managers were charged by Los Angeles prosecutors Monday with violating safety regulations in the death of a worker ...

       
 
Ed Miliband in Russell Brand interview: I will stand up to global business
2015-04-28 13:51:41 (25 minutes ago) 

Clip from comedian’s interview with Labour leader shows Miliband pressed over how much influence nations can have over transnational companies

Ed Miliband has sought to persuade the comedian Russell Brand that he would stand up to global businesses, in an extract of an interview the famously anti-corporate comedian conducted with the Labour leader.

In the clip, Brand presses Miliband over how far nations can “leverage serious influence” over transnational companies in a globalised world. Miliband concedes that it is difficult but insists that measures can be taken unilaterally.

Related: David Cameron mocks Ed Miliband over Russell Brand interview

Continue reading...
 
Dispute outside church leaves 2 fatally shot, 4 injured
2015-04-28 13:51:36 (25 minutes ago) 
 
Wild vs. Blackhaws schedule released for semifinals
2015-04-28 13:51:34 (25 minutes ago) 
Conference semifinals schedule
 
Los Angeles man charged in San Bernardino marijuana dispensary slaying
2015-04-28 13:51:25 (25 minutes ago) 

SAN BERNARDINO >> A Los Angeles man has been charged with the deadly shooting of a security guard at a medical marijuana dispensary back in February.

Curtis James Jackson, 21, was charged Monday with murder and burglary, according to the criminal complaint filed by the San Bernardino County District Attorney's Office, in connection to the death of Anthony Pineda, 25, of Rowland Heights.

 
Association between Plasma 25-Hydroxyvitamin D, Ancestry and Aggressive Prostate Cancer among African Americans and European Americans in PCaP
2015-04-28 13:51:21 (25 minutes ago) 

by Susan E. Steck, Lenore Arab, Hongmei Zhang, Jeannette T. Bensen, Elizabeth T. H. Fontham, Candace S. Johnson, James L. Mohler, Gary J. Smith, Joseph L. Su, Donald L. Trump, Anna Woloszynska-Read

Background

African Americans (AAs) have lower circulating 25-hydroxyvitamin D3 [25(OH)D3] concentrations and higher prostate cancer (CaP) aggressiveness than other racial/ethnic groups. The purpose of the current study was to examine the relationship between plasma 25(OH)D3, African ancestry and CaP aggressiveness among AAs and European Americans (EAs).

Methods

Plasma 25(OH)D3 was measured using LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometry) in 537 AA and 663 EA newly-diagnosed CaP patients from the North Carolina-Louisiana Prostate Cancer Project (PCaP) classified as having either ‘high’ or ‘low’ aggressive disease based on clinical stage, Gleason grade and prostate specific antigen at diagnosis. Mean plasma 25(OH)D3 concentrations were compared by proportion of African ancestry. Logistic regression was used to calculate multivariable adjusted odds ratios (OR) and 95% confidence intervals (95%CI) for high aggressive CaP by tertile of plasma 25(OH)D3.

Results

AAs with highest percent African ancestry (>95%) had the lowest mean plasma 25(OH)D3 concentrations. Overall, plasma 25(OH)D3 was associated positively with aggressiveness among AA men, an association that was modified by calcium intake (ORT3vs.T1: 2.23, 95%CI: 1.26–3.95 among men with low calcium intake, and ORT3vs.T1: 0.19, 95%CI: 0.05–0.70 among men with high calcium intake). Among EAs, the point estimates of the ORs were

 
On-Off Kinetics of Engagement of FNI Modules of Soluble Fibronectin by β-Strand Addition
2015-04-28 13:51:21 (25 minutes ago) 

by Wenjiang Ma, Hanqing Ma, Deane F. Mosher

Intrinsically disordered sequences within bacterial adhesins bind to E-strands in the β-sheets of multiple FNI modules of fibronectin (FN) by anti-parallel β-strand addition, also called tandem β-zipper formation. The FUD segment of SfbI of Streptococcus pyogenes and Bbk32 segment of BBK32 of Borrelia burgdorferi, despite being imbedded in different adhesins from different bacteria, target the same FNI modules, 2–5,8–9FNI, in the N-terminal 70-kDa region (FN70K) of FN. To facilitate further comparisons, FUD, Bbk32, two other polypeptides based on SfbI that target 1–5FNI (HADD) and 2–5FNI (FRD), and mutant Bbk32 (ΔBbk32) were produced with fluorochromes placed just outside of the binding sequences. Unlabeled FUD competed ~1000-fold better for binding of labeled Bbk32 to FN than unlabeled Bbk32 competed for binding of labeled FUD to FN. Binding kinetics were determined by fluorescence polarization in a stopped-flow apparatus. On-rates for FUD, Bbk32, HADD, and FRD were similar, and all bound more rapidly to FN70K fragment than to full length FN. In stopped-flow displacement and size exclusion chromatographic assays, however, koff for FUD or HADD to FN70K or FN was considerably lower compared to koff of FRD or Bbk32. FUD and Bbk32 differ in the spacing between sequences that interact with 3FNI and 4FNI or with 5FNI and 8FNI. ΔBbk32, in which 2 residues were removed from Bbk32 to make the spacing more like FUD, had a koff intermediate between that of Bbk32 and FUD. These results indicate a “folding-after-binding” process after initial association of certain polypeptide sequences to FN that results in formation of a stable complex and is a function of number of FNI modules engaged by the polypeptide, spacing of engagement sites, and perhaps flexibility within the polypeptide-FN complex. We suggest that contributions of SfbI and BBK32 adhesins to bacterial pathogenicity may be determined in part by stability of adhesin-FN complexes.
 
Pathway for Biodegrading Microcystin-YR by Sphingopyxis sp. USTB-05
2015-04-28 13:51:21 (25 minutes ago) 

by Huimin Xu, Huasheng Wang, Qianqian Xu, Le Lv, Chunhua Yin, Xiaolu Liu, Hongwu Du, Hai Yan

Harmful cyanobacterial blooms in waters have become a global environmental problem, this mainly due to the production and release of various microalgal toxins, in which microcystins (MCs) are distributed widely. Here, we focused on the study of a typical form of microcystins called microcystin-YR (MC-YR). It was found that initial 14.8 mg/L of MC-YR could be completely eliminated within 10 hr by the crude enzymes (CEs) of Sphingopyxis sp. USTB-05, a promising bacterial strain we isolated and identified in our previous study. During the enzymatic biodegradation of MC-YR with time course, the peaks of two intermediate and two final products were observed on the profiles of HPLC at the wavelengths of 238 nm and 230 nm, respectively. Based on the analysis of m/z ratios of MC-YR and its four products by LC-MS/MS, we suggested that at least four enzymes were involved in the biodegradation of MC-YR by Sphingopyxis sp. USTB-05. The first enzyme microcystinase converted cyclic MC-YR to linear MC-YR as the first product. Then the second enzyme serine protease was found to cleave the target peptide bond between alanine (Ala) and tyrosine (Tyr) of linearized MC-YR, producing a tetrapeptide and a tripeptide as second products, which were Adda-Glu-Mdha-Ala and Tyr-Masp-Arg, respectively. Next, the third enzyme peptidase converted the tetrapeptide of Adda-Glu-Mdha-Ala to Adda. And the fourth enzyme cleaved the tripeptide of Tyr-Masp-Arg to produce Tyr and dipeptide (Masp-Arg), which has never been reported. These findings will help us better understand the biodegradation pathway of MC-YR by Sphingopyxis sp. USTB-05.
 
Phylogeography of a Marine Insular Endemic in the Atlantic Macaronesia: The Azorean Barnacle, Megabalanus azoricus (Pilsbry, 1916)
2015-04-28 13:51:21 (25 minutes ago) 

by Javier Quinteiro, Pablo Manent, Lois Pérez-Diéguez, José A. González, Corrine Almeida, Evandro Lopes, Ricardo Araújo, Gilberto P. Carreira, Manuel Rey-Méndez, Nieves González-Henríquez

The Azorean barnacle, Megabalanus azoricus (Pilsbry, 1916), is a Macaronesian endemic whose obscure taxonomy and the unknown relationships among forms inhabiting isolated Northern Atlantic oceanic islands is investigated by means of molecular analysis herein. Mitochondrial data from the 16S rRNA and COX1 genes support its current species status, tropical ancestry, and the taxonomic homogeneity throughout its distribution range. In contrast, at the intraspecific level and based on control region sequences, we detected an overall low level of genetic diversity and three divergent lineages. The haplogroups α and γ were sampled in the Azores, Madeira, Canary, and Cabo Verde archipelagos; whereas haplogroup β was absent from Cabo Verde. Consequently, population analysis suggested a differentiation of the Cabo Verde population with respect to the genetically homogenous northern archipelagos generated by current oceanographic barriers. Furthermore, haplogroup α, β, and γ demographic expansions occurred during the interglacial periods MIS5 (130 Kya - thousands years ago -), MIS3 (60 Kya), and MIS7 (240 Kya), respectively. The evolutionary origin of these lineages is related to its survival in the stable southern refugia and its demographic expansion dynamics are associated with the glacial-interglacial cycles. This phylogeographic pattern suggests the occurrence of genetic discontinuity informative to the delimitation of an informally defined biogeographic entity, Macaronesia, and its generation by processes that delineate genetic diversity of marine taxa in this area.
 
Enhanced IMP3 Expression Activates NF-кB Pathway and Promotes Renal Cell Carcinoma Progression
2015-04-28 13:51:21 (25 minutes ago) 

by Xuelian Pei, Muhan Li, Jun Zhan, Yu Yu, Xiaofan Wei, Lizhao Guan, Hakan Aydin, Paul Elson, Ming Zhou, Huiying He, Hongquan Zhang

Background

Insulin-like growth factor 2 mRNA binding protein 3 (IMP3) is expressed in metastatic and a subset of primary renal cell carcinoma (RCC). However, the role of IMP3 in RCC progression was poorly understood. We aim to uncover the mechanism of IMP3 in regulating clear cell RCC (CCRCC) progression and validate the prognostic significance of IMP3 in localized CCRCC.

Methods

Caki-1 cells stably overexpressing IMP3 and Achn cells with knockdown of IMP3 were analyzed for cell migration and invasion by Transwell assay. RNA-seq was used to profile gene expression in IMP3-expressing Caki-1 cells. A cohort of 469 localized CCRCC patients were examined for IMP3 expression by immunohistochemistry using tumor tissue array.

Results

IMP3 promoted Caki-1 cell migration and invasion, whereas knockdown of IMP3 by RNAi inhibited Achn cell migration and invasion. Enhanced IMP3 expression activated NF-кB pathway and through which, it functioned in promoting the RCC cell migration. IMP3 expression in localized CCRCC was found to be associated with higher nuclear grade, higher T stage, necrosis and sarcomatoid differentiation (p< 0.001). Enhanced IMP3 expression was correlated with shorter recurrence-free and overall survivals. Multivariable analysis validated IMP3 as an independent prognostic factor for localized CCRCC patients.

Conclusion

IMP3 promotes RCC cell migration and invasion by activation of NF-кB pathway. IMP3 is validated to be an independent prognostic marker for localized CCRCC.

 
Latent Tuberculosis Infection and Associated Factors among Health Care Workers in Kigali, Rwanda
2015-04-28 13:51:21 (25 minutes ago) 

by Claude Rutanga, David W. Lowrance, John E. Oeltmann, Grace Mutembayire, Matt Willis, Claude Bernard Uwizeye, Ruton Hinda, Chitou Bassirou, Steve Gutreuter, Michel Gasana

Introduction

Data are limited regarding tuberculosis (TB) and latent TB infection prevalence in Rwandan health facilities.

Methods

We conducted a cross-sectional survey among healthcare workers (HCWs) in Kigali during 2010. We purposively selected the public referral hospital, both district hospitals, and randomly selected 7 of 17 health centers. School workers (SWs) from the nearest willing public schools served as a local reference group. We tested for latent TB infection (LTBI) using tuberculin skin testing (TST) and asked about past TB disease. We assessed risk of LTBI and past history of TB disease associated with hospital employment. Among HCWs, we assessed risk associated with facility type (district hospital, referral hospital, health center), work setting (inpatient, outpatient), and occupation.

Results

Age, gender, and HIV status was similar between the enrolled 1,131 HCWs and 381 SWs. LTBI was more prevalent among HCWs (62%) than SWs (39%). Adjusted odds of a positive TST result were 2.71 (95% CI 2.01–3.67) times greater among HCWs than SWs. Among HCWs, there was no detectable difference between prevalence of LTBI according to facility type, work setting, or occupation.

Conclusion

HCWs are at greater risk of LTBI, regardless of facility type, work setting, or occupation. The current status of TB infection control practices should be evaluated in the entire workforce in all Rwandan healthcare facilities.

 
Molecular Dynamics Simulations of the Human Glucose Transporter GLUT1
2015-04-28 13:51:21 (25 minutes ago) 

by Min-Sun Park

Glucose transporters (GLUTs) provide a pathway for glucose transport across membranes. Human GLUTs are implicated in devastating diseases such as heart disease, hyper- and hypo-glycemia, type 2 diabetes and caner. The human GLUT1 has been recently crystalized in the inward-facing open conformation. However, there is no other structural information for other conformations. The X-ray structures of E. coli Xylose permease (XylE), a glucose transporter homolog, are available in multiple conformations with and without the substrates D-xylose and D-glucose. XylE has high sequence homology to human GLUT1 and key residues in the sugar-binding pocket are conserved. Here we construct a homology model for human GLUT1 based on the available XylE crystal structure in the partially occluded outward-facing conformation. A long unbiased all atom molecular dynamics simulation starting from the model can capture a new fully opened outward-facing conformation. Our investigation of molecular interactions at the interface between the transmembrane (TM) domains and the intracellular helices (ICH) domain in the outward- and inward-facing conformation supports that the ICH domain likely stabilizes the outward-facing conformation in GLUT1. Furthermore, inducing a conformational transition, our simulations manifest a global asymmetric rocker switch motion and detailed molecular interactions between the substrate and residues through the water-filled selective pore along a pathway from the extracellular to the intracellular side. The results presented here are consistent with previously published biochemical, mutagenesis and functional studies. Together, this study shed light on the structure and functional relationships of GLUT1 in multiple conformational states.
 
532 nm Low-Power Laser Irradiation Facilitates the Migration of GABAergic Neural Stem/Progenitor Cells in Mouse Neocortex
2015-04-28 13:51:21 (25 minutes ago) 

by Yumi Fukuzaki, Hyeryun Shin, Hideki D. Kawai, Banri Yamanoha, Shinichi Kogure

Background and Objective

Accumulating evidence has shown that low-power laser irradiation (LLI) affects cell proliferation and survival, but little is known about LLI effects on neural stem/progenitor cells (NSPCs). Here we investigate whether transcranial 532 nm LLI affects NSPCs in adult murine neocortex and in neurospheres from embryonic mice.

Study Design/Materials and Methods

We applied 532 nm LLI (Nd:YVO4, CW, 60 mW) on neocortical surface via cranium in adult mice and on cultured cells from embryonic mouse brains in vitro to investigate the proliferation and migration of NSPCs and Akt expression using immunohistochemical assays and Western blotting techniques.

Results

In vivo experiments demonstrated that 532 nm LLI significantly facilitated the migration of GABAergic NSPCs that were induced to proliferate in layer 1 by mild ischemia. In vitro experiments using GABAergic NSPCs derived from embryonic day 14 ganglionic eminence demonstrated that 532 nm LLI for 60 min promoted the migration of GAD67-immunopositive NSPCs with a significant increase of Akt expression. Meanwhile, the LLI induced proliferation, but not migration, of NSPCs that give rise to excitatory neurons.

Conclusion

It is concluded that 532 nm LLI promoted the migration of GABAergic NSPCs into deeper layers of the neocortex in vivo by elevating Akt expression.

 
N.J. sending state troopers to Baltimore
2015-04-28 13:51:15 (26 minutes ago) 
New Jersey is deploying 150 state police and other personnel to Baltimore, Gov. Christie said Tuesday, a day after riots broke out in the city.
 
Six out of 10 overcome cancer in Italy
2015-04-28 13:51:12 (26 minutes ago) 
Cancer-related deaths down by 20% since 1996






 
Baltimore riots: Residents start to clean up glass, debris after riots during uneasy peace
2015-04-28 13:51:06 (26 minutes ago) 

Baltimore's residents gathered Tuesday in the part of the city hit hardest by the riots and began the slow process of cleaning up after disgruntled citizens and opportunists set fire Monday to cop cars and vandalized stores in the hours following Freddie Gray's funeral.

More than 100 people collected trash, ...

 
President Obama on Baltimore riots: "No excuse" for destruction
2015-04-28 13:51:01 (26 minutes ago) 
President Obama spoke on the violence and unrest that broke out on the streets of Baltimore, saying there was "no excuse" for the destruction. He spoke at a joint press conference with Japanese Prime Minister Shinzo Abe.
 
Creative Commons License
Free Internet Press is licensed under a Creative Commons Attribution 3.0 United States License. You may reuse or distribute original works on this site, with attribution per the above license.

Any mirrored or quoted materials may be copyright their respective authors, publications, or outlets, as shown on their publication, indicated by the link in the news story. Such works are used under the fair use doctrine of United States copyright law. Should any materials be found overused or objectionable to the copyright holder, notification should be sent to editor@freeinternetpress.com, and the work will be removed and replaced with such notification.

Please email editor@freeinternetpress.com with any questions.

Our Privacy Policy can be viewed at https://freeinternetpress.com/privacy_policy.php

XML/RSS/RDF Newsfeed Syndication XML/RSS/RDF Newsfeed Syndication: http://freeinternetpress.com/rss.php

XML/RSS/RDF Newsfeed Syndication XML News Sitemap